外周循环肿瘤细胞

血管内肿瘤细胞
(重定向自循環腫瘤細胞

外周循环肿瘤细胞(Circulating Tumor Cell,简称CTC),是指由肿瘤组织脱落后,进入血管淋巴管系统中的肿瘤细胞[1], 由于其可以借由血液循环扩散至其他器官,进而形成肿瘤远端转移的能力,常被称为癌症转移的“种子”(seeds)。 [2] CTC的检测与分析可以协助癌症早期诊断及个人化疗等治疗手段的选择 [3],其中一种名为CellSearch的方法在乳腺癌结肠直肠癌前列腺癌的诊断上已受美国食品药物管理局核可。 [4]

参考资料

编辑
  1. ^ Riquet, M; Rivera, C; Gibault, L; Pricopi, C; Mordant, P; Badia, A; Arame, A; Le Pimpec Barthes, F. [Lymphatic spread of lung cancer: anatomical lymph node chains unchained in zones]. Revue de Pneumologie Clinique. 2014, 70 (1–2): 16–25. PMID 24566031. doi:10.1016/j.pneumo.2013.07.001. 
  2. ^ Gupta, GP; Massagué, J. Cancer metastasis: building a framework. Cell. Nov 17, 2006, 127 (4): 679–95. PMID 17110329. S2CID 7362869. doi:10.1016/j.cell.2006.11.001 . 
  3. ^ Rack B, Schindlbeck C, Jückstock J, Andergassen U, Hepp P, Zwingers T, Friedl T, Lorenz R, Tesch H, Fasching P, Fehm T, Schneeweiss A, Lichtenegger W, Beckmann M, Friese K, Pantel K, Janni W. Circulating Tumor Cells Predict Survival in Early Average-to-High Risk Breast Cancer Patients. Journal of the National Cancer Institute. 2014, 106 (5). PMC 4112925 . PMID 24832787. doi:10.1093/jnci/dju066. 
  4. ^ Millner, LM; Linder, MW; Valdes R, Jr. Circulating tumor cells: a review of present methods and the need to identify heterogeneous phenotypes.. Annals of Clinical and Laboratory Science. Summer 2013, 43 (3): 295–304. PMC 5060940 . PMID 23884225.