细胞增殖

细胞增殖是指细胞生长和分裂成两个子细胞的过程^[1]^[2]^[3]^[4]。细胞增殖使细胞数量成倍增加，因此它是组织生长的快速机制。细胞增殖要求细胞生长和细胞分裂同时发生，以使细胞的平均大小保持不变。细胞增殖与细胞生长或细胞分裂不同的是，细胞分裂时可以不发生细胞生长，这样会生成许多小细胞(如卵裂)，而细胞生长可以不发生细胞分裂，因而会产生单个较大的细胞(如神经元的生长)^[5]。细胞总数由细胞增殖率减去细胞死亡率所决定。

参考

^ Conlon, Ian; Raff, Martin. Size Control in Animal Development. Cell. 1999, 96 (2): 235–244. ISSN 0092-8674. PMID 9988218. doi:10.1016/S0092-8674(00)80563-2.
^ Grewal, Savraj S; Edgar, Bruce A. Controlling cell division in yeast and animals: does size matter?. Journal of Biology. 2003, 2 (1): 5. ISSN 1475-4924. PMID 12733996. doi:10.1186/1475-4924-2-5.
^ Neufeld, Thomas P; de la Cruz, Aida Flor A; Johnston, Laura A; Edgar, Bruce A. Coordination of Growth and Cell Division in the Drosophila Wing. Cell. 1998, 93 (7): 1183–1193. ISSN 0092-8674. PMID 9657151. doi:10.1016/S0092-8674(00)81462-2.
^ Thompson, Barry J. Developmental control of cell growth and division in Drosophila. Current Opinion in Cell Biology. 2010, 22 (6): 788–794. PMID 20833011. doi:10.1016/j.ceb.2010.08.018.
^ Saucedo, L. Why size matters: altering cell size. Current Opinion in Genetics & Development. 2002, 12 (5): 565–571. ISSN 0959-437X. PMID 12200162. doi:10.1016/S0959-437X(02)00341-6.

[ConlonRaff1999-1] Conlon, Ian; Raff, Martin. Size Control in Animal Development. Cell. 1999, 96 (2): 235–244. ISSN 0092-8674. PMID 9988218. doi:10.1016/S0092-8674(00)80563-2.

[GrewalEdgar2003-2] Grewal, Savraj S; Edgar, Bruce A. Controlling cell division in yeast and animals: does size matter?. Journal of Biology. 2003, 2 (1): 5. ISSN 1475-4924. PMID 12733996. doi:10.1186/1475-4924-2-5.

[Neufeldde_la_Cruz1998-3] Neufeld, Thomas P; de la Cruz, Aida Flor A; Johnston, Laura A; Edgar, Bruce A. Coordination of Growth and Cell Division in the Drosophila Wing. Cell. 1998, 93 (7): 1183–1193. ISSN 0092-8674. PMID 9657151. doi:10.1016/S0092-8674(00)81462-2.

[Thompson-4] Thompson, Barry J. Developmental control of cell growth and division in Drosophila. Current Opinion in Cell Biology. 2010, 22 (6): 788–794. PMID 20833011. doi:10.1016/j.ceb.2010.08.018.

[Saucedo2002-5] Saucedo, L. Why size matters: altering cell size. Current Opinion in Genetics & Development. 2002, 12 (5): 565–571. ISSN 0959-437X. PMID 12200162. doi:10.1016/S0959-437X(02)00341-6.

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