骨质软化

骨质软化
骨质软化
	胆钙化醇（维生素D3）的缺乏是引起骨质软化最常见的原因
类型	bone remodeling disease[*]、疾病
分类和外部资源
医学专科	风湿病学
ICD-11	FB83.2
ICD-10	M83
ICD-9-CM	268.2
DiseasesDB	9351
MedlinePlus	000376
eMedicine	985510、412862
	[编辑此条目的维基数据]

骨质软化（英语：Osteomalacia）又称软骨病，是一种因骨骼代谢障碍而引起的骨骼软化疾病，引起骨骼代谢（英语：Bone remodeling）障碍的原因有人体缺乏磷酸盐、钙和维生素D，或是钙的骨质吸收作用。儿童要是出现骨质疏松则称为佝偻病，正因为如此，骨质疏松症这一称呼常用于程度较轻的成人患者。骨质软化的症状和体征有身体出现弥漫性疼痛、肌肉无力和脆弱的骨骼^[1]^[2]^[3]^[4]^[5]。及时补充维生素D和钙可以预防和治疗骨质软化^[6]。

参考文献

^ Salmon, B; Bardet, C; Coyac, BR; Baroukh, B; Naji, J; Rowe, PS; Opsahl Vital, S; Linglart, A; Mckee, MD. Abnormal osteopontin and matrix extracellular phosphoglycoprotein localization, and odontoblast differentiation, in X-linked hypophosphatemic teeth.. Connective Tissue Research. August 2014,. 55 Suppl 1: 79–82. PMID 25158186. doi:10.3109/03008207.2014.923864.
^ Boukpessi, T; Hoac, B; Coyac, BR; Leger, T; Garcia, C; Wicart, P; Whyte, MP; Glorieux, FH; Linglart, A. Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia.. Bone. 21 November 2016, 95: 151–161. PMID 27884786. doi:10.1016/j.bone.2016.11.019.
^ Barros, NM; Hoac, B; Neves, RL; Addison, WN; Assis, DM; Murshed, M; Carmona, AK; McKee, MD. Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia.. Journal of Bone and Mineral Research. March 2013, 28 (3): 688–99. PMID 22991293. doi:10.1002/jbmr.1766.
^ McKee, MD; Hoac, B; Addison, WN; Barros, NM; Millán, JL; Chaussain, C. Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia.. Periodontology 2000. October 2013, 63 (1): 102–22. PMC 3766584  . PMID 23931057. doi:10.1111/prd.12029.
^ Boukpessi, T; Gaucher, C; Léger, T; Salmon, B; Le Faouder, J; Willig, C; Rowe, PS; Garabédian, M; Meilhac, O. Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.. The American Journal of Pathology. August 2010, 177 (2): 803–12. PMC 2913338  . PMID 20581062. doi:10.2353/ajpath.2010.091231.
^ Longo, Dan L.; et al. Harrison's principles of internal medicine. 18th. New York: McGraw-Hill. 2012. ISBN 978-0-07174889-6.

[1] Salmon, B; Bardet, C; Coyac, BR; Baroukh, B; Naji, J; Rowe, PS; Opsahl Vital, S; Linglart, A; Mckee, MD. Abnormal osteopontin and matrix extracellular phosphoglycoprotein localization, and odontoblast differentiation, in X-linked hypophosphatemic teeth.. Connective Tissue Research. August 2014,. 55 Suppl 1: 79–82. PMID 25158186. doi:10.3109/03008207.2014.923864.

[2] Boukpessi, T; Hoac, B; Coyac, BR; Leger, T; Garcia, C; Wicart, P; Whyte, MP; Glorieux, FH; Linglart, A. Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia.. Bone. 21 November 2016, 95: 151–161. PMID 27884786. doi:10.1016/j.bone.2016.11.019.

[3] Barros, NM; Hoac, B; Neves, RL; Addison, WN; Assis, DM; Murshed, M; Carmona, AK; McKee, MD. Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia.. Journal of Bone and Mineral Research. March 2013, 28 (3): 688–99. PMID 22991293. doi:10.1002/jbmr.1766.

[4] McKee, MD; Hoac, B; Addison, WN; Barros, NM; Millán, JL; Chaussain, C. Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia.. Periodontology 2000. October 2013, 63 (1): 102–22. PMC 3766584  . PMID 23931057. doi:10.1111/prd.12029.

[5] Boukpessi, T; Gaucher, C; Léger, T; Salmon, B; Le Faouder, J; Willig, C; Rowe, PS; Garabédian, M; Meilhac, O. Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.. The American Journal of Pathology. August 2010, 177 (2): 803–12. PMC 2913338  . PMID 20581062. doi:10.2353/ajpath.2010.091231.

[auto-6] Longo, Dan L.; et al. Harrison's principles of internal medicine. 18th. New York: McGraw-Hill. 2012. ISBN 978-0-07174889-6.

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