那呐妥单抗

那呐妥单抗
单克隆抗体
种类	完整抗体
目标	RON（英语：MST1R）
临床资料
ATC码	未分配;
识别信息
CAS号	1188275-92-4
ChemSpider	none;
UNII	R42YK40U9M;
KEGG	D10074;
化学信息
化学式	C6454H10026N1754O2020S44
摩尔质量	145,922.10 g·mol−1

那呐妥单抗（INN：Narnatumab；开发代号：IMC-RON8、LY3012219）^[1]是一种针对RON（英语：MST1R）受体的人单克隆抗体，设计用于治疗直肠癌和由淋巴管生成（英语：Lymphangiogenesis）引起的实体瘤。^[2]该药物目前已经进行了I期临床试验。^[1]^[2]^[3]

那呐妥单抗由ImClone Systems（英语：ImClone Systems）开发。^[4]

参考资料

^ ^1.0 ^1.1 LoRusso, Patricia M.; Gounder, Mrinal; Jalal, Shadia I.; André, Valérie; Kambhampati, Siva Rama Prasad; Loizos, Nick; Hall, Jennifer; Holzer, Timothy R.; Nasir, Aejaz; Cosaert, Jan; Kauh, John. Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors. Investigational New Drugs. 2017-08, 35 (4) [2024-01-24]. ISSN 1573-0646. PMC 5502198  . PMID 28161886. doi:10.1007/s10637-016-0413-0. （原始内容存档于2024-01-24）.
^ ^2.0 ^2.1 Saif, Muhammad Wasif; Knost, James A.; Chiorean, E. Gabriela; Kambhampati, Siva Rama Prasad; Yu, Danni; Pytowski, Bronislaw; Qin, Amy; Kauh, John S.; O'Neil, Bert H. Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer. Cancer Chemotherapy and Pharmacology. 2016-10, 78 (4) [2024-01-24]. ISSN 1432-0843. PMID 27566701. doi:10.1007/s00280-016-3134-3. （原始内容存档于2024-03-22）.
^ Yu Koh, Xin; Koh, Xin Yu; Xiao Hui Koh; Spiegelberg, Diana; Jha, Preeti; Nestor, Marika; Hwang, Le-ann; Tan, Ban Xiong; Lane, David Philip. Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy. Scientific Reports. 2022-12-29, 12 (1) [2024-01-24]. ISSN 2045-2322. doi:10.1038/s41598-022-26404-7. （原始内容存档于2024-01-24）（英语）.
^ Narnatumumab. AdisInsight. [31 January 2017]. （原始内容存档于2024-01-24）.

[:0-1] 1.0 ^1.1 LoRusso, Patricia M.; Gounder, Mrinal; Jalal, Shadia I.; André, Valérie; Kambhampati, Siva Rama Prasad; Loizos, Nick; Hall, Jennifer; Holzer, Timothy R.; Nasir, Aejaz; Cosaert, Jan; Kauh, John. Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors. Investigational New Drugs. 2017-08, 35 (4) [2024-01-24]. ISSN 1573-0646. PMC 5502198  . PMID 28161886. doi:10.1007/s10637-016-0413-0. （原始内容存档于2024-01-24）.

[:1-2] 2.0 ^2.1 Saif, Muhammad Wasif; Knost, James A.; Chiorean, E. Gabriela; Kambhampati, Siva Rama Prasad; Yu, Danni; Pytowski, Bronislaw; Qin, Amy; Kauh, John S.; O'Neil, Bert H. Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer. Cancer Chemotherapy and Pharmacology. 2016-10, 78 (4) [2024-01-24]. ISSN 1432-0843. PMID 27566701. doi:10.1007/s00280-016-3134-3. （原始内容存档于2024-03-22）.

[3] Yu Koh, Xin; Koh, Xin Yu; Xiao Hui Koh; Spiegelberg, Diana; Jha, Preeti; Nestor, Marika; Hwang, Le-ann; Tan, Ban Xiong; Lane, David Philip. Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy. Scientific Reports. 2022-12-29, 12 (1) [2024-01-24]. ISSN 2045-2322. doi:10.1038/s41598-022-26404-7. （原始内容存档于2024-01-24）（英语）.

[4] Narnatumumab. AdisInsight. [31 January 2017]. （原始内容存档于2024-01-24）.

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