3-甲氧基吗喃
化合物
3-甲氧基吗喃（英语：3-Methoxymorphinan）是一种含氮有机化合物，化学式C17H23NO，具有局部麻醉作用[1]，在体内由酶CYP3A4催化右美沙芬生成,[2]，再由肝脏中的酶CYP2D6代谢[3]。
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| 识别信息 | |
| CAS号 | 1531-25-5  |
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| ECHA InfoCard | 100.014.764 |
| 化学信息 | |
| 化学式 | C17H23NO |
| 摩尔质量 | 257.38 g·mol−1 |
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参考文献
编辑- ^ Hou CH, Tzeng JI, Chen YW, Lin CN, Lin MT, Tu CH, Wang JJ. Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats. European Journal of Pharmacology. August 2006, 544 (1–3): 10–16. PMID 16844109. doi:10.1016/j.ejphar.2006.06.013.
- ^ Min DI, Ku YM, Vichiendilokkul A, Fleckenstein LL. A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers. Pharmacotherapy. June 1999, 19 (6): 753–759. PMID 10391422. S2CID 32243163. doi:10.1592/phco.19.9.753.31536.
- ^ Strauch K, Lutz U, Bittner N, Lutz WK. Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. Food and Chemical Toxicology. August 2009, 47 (8): 1928–1935. PMID 19445995. doi:10.1016/j.fct.2009.05.004.