ZR-75-1细胞

ZR-75-1是人类乳癌细胞系^[1]。在长期缺乏类固醇的情况下，对雌激素敏感的人类乳癌克隆细胞在生长时，会产生对雌激素不敏感的细胞。在ZR-75-1细胞中，这种作用的发生频率很高，提示这个机制可以同时影响很大一部分的细胞群^[2]。有研究利用ZR-75-1细胞，证明了雄激素和雌激素之间，对GCDFP-15和GCDFP-24表达的拮抗作用，GCDFP-15和GCDFP-24是人类毛囊性疾病液中分泌的两种主要蛋白质^[1]。

参考资料

^ ^1.0 ^1.1 Dorssers, LC; van Agthoven, T. Genetic mechanisms of estrogen-independence in breast cancer.. Pathology, research and practice. 1996-07, 192 (7): 743–51 [2019-11-28]. PMID 8880875. doi:10.1016/S0344-0338(96)80096-3.
^ Labrie, F; Simard, J; de Launoit, Y; Poulin, R; Thériault, C; Dumont, M; Dauvois, S; Martel, C; Li, SM. Androgens and breast cancer.. Cancer detection and prevention. 1992, 16 (1): 31–8 [2019-11-28]. PMID 1551135.

外部链接

Cellosaurus entry for ZR-75-1 （页面存档备份，存于互联网档案馆）

[#1-1] 1.0 ^1.1 Dorssers, LC; van Agthoven, T. Genetic mechanisms of estrogen-independence in breast cancer.. Pathology, research and practice. 1996-07, 192 (7): 743–51 [2019-11-28]. PMID 8880875. doi:10.1016/S0344-0338(96)80096-3.

[2] Labrie, F; Simard, J; de Launoit, Y; Poulin, R; Thériault, C; Dumont, M; Dauvois, S; Martel, C; Li, SM. Androgens and breast cancer.. Cancer detection and prevention. 1992, 16 (1): 31–8 [2019-11-28]. PMID 1551135.

[1]

[2]