依泊二醇(英语:Epomediol,商品名Clesidren)是一种人工合成的类萜物质,分子式C10H18O3,有利胆剂英语Choleretic的作用,可用于对症治疗妊娠期肝内胆汁淤积英语Intrahepatic cholestasis of pregnancy引起的骚[2][3][4]

依泊二醇
Skeletal formula
Ball-and-stick model
临床资料
ATC码
识别信息
  • (1s,4r,6R,7S)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane-6,7-diol
CAS号56084-15-2  checkY
PubChem CID
ChemSpider
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C10H18O3
摩尔质量186.25 g·mol−1
3D模型(JSmol英语JSmol
熔点125[1] °C(257 °F)
  • OC1CC2C(OC1(C)C(O)C2)(C)C

参考文献

编辑
  1. ^ Kozlov, N. G.; Prishchepenko, V. M.; Biba, V. I.; Shavyrin, S. V.; Popova, L. A. 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]​octane-6,7-diol. 1987 SU 1346638 A1.
  2. ^ Gonzalez MC, Iglesias J, Tiribelli C, et al. Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy. J Hepatol. September 1992, 16 (1–2): 241–2. PMID 1484159. doi:10.1016/S0168-8278(05)80122-9. 
  3. ^ Reyes H. The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy. Gastroenterol Clin North Am. December 1992, 21 (4): 905–21. PMID 1478743. 
  4. ^ Reyes H, Simon FR. Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin Liver Dis. August 1993, 13 (3): 289–301. PMID 8235718. doi:10.1055/s-2007-1007357.