依法西泮

化合物

依法西泮(英语:Elfazepam[1])是一种药物,是苯二氮䓬类衍生物。[2]据推测,它与其他苯二氮䓬类药物一样具有镇静抗焦虑作用。

依法西泮
临床资料
ATC码
  • 未分配
识别信息
  • 7-Chloro-1-(2-ethylsulfonylethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
CAS号52042-01-0  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C19H18ClFN2O3S
摩尔质量408.87
3D模型(JSmol英语JSmol
  • O=S(CC)(CCN1C(CN=C(C2=CC=CC=C2F)C3=C1C=CC(Cl)=C3)=O)=O
  • InChI=1S/C19H18ClFN2O3S/c1-2-27(25,26)10-9-23-17-8-7-13(20)11-15(17)19(22-12-18(23)24)14-5-3-4-6-16(14)21/h3-8,11H,2,9-10,12H2,1H3 checkY
  • Key:BSPSXMXQKZZNFP-UHFFFAOYSA-N checkY

该药物在动物体内具有食欲特性。[3][4]该药物增加进食量的机制尚不清楚,并且一直在进行研究中。[5]已发现依法西泮能够抑制胃酸的分泌。[6]

合成

编辑
 
依法西泮合成:U.S. Patent 4,010,154

二苯甲酮衍生物(1)与掩蔽为2,5-𫫇唑烷二酮(2)的甘氨酸等效物反应,得到最终产物(3)依法西泮。

参考资料

编辑
  1. ^ 美国专利第4,010,154号
  2. ^ Psychotropics.dk
  3. ^ Baile CA, McLaughlin CL. A review of the behavioral and physiological responses to elfazepam, a chemical feed intake stimulant. Journal of Animal Science. November 1979, 49 (5): 1371–95. PMID 396294. doi:10.2527/jas1979.4951371x. 
  4. ^ Baile CA, Naylor J, McLaughlin CL, Catanzaro CA. Endotoxin-elicited fever and anorexia and elfazepam-stimulated feeding in sheep. Physiology & Behavior. August 1981, 27 (2): 271–7. PMID 7029576. S2CID 12408796. doi:10.1016/0031-9384(81)90269-9. 
  5. ^ Keim DA, Baile CA, Bolton JR, Wangsness PJ, Della Fera MA. Abomasal function following injections of elfazepam and 9-aza-cannabinol. Pharmacology, Biochemistry, and Behavior. January 1979, 10 (1): 63–70. PMID 35793. S2CID 915512. doi:10.1016/0091-3057(79)90170-9. 
  6. ^ Van Den Broek GW, Robertson J, Keim DA, Baile CA. Feeding and depression of abomasal secretion in sheep elicited by elfazepam and 9-aza-cannabinol. Pharmacology, Biochemistry, and Behavior. July 1979, 11 (1): 51–6. PMID 493298. S2CID 33152825. doi:10.1016/0091-3057(79)90296-x.