姐妹染色单体交换

姐妹染色单体交换（英语：sister chromatid exchange，缩写 SCE），是两条相同的姐妹染色单体之间的遗传物质交换。

这是在有丝分裂后期之前，利用吉姆萨染色法在一条属于姐妹染色单体复合物的染色单体上首次发现的。染色显示，少数染色的片段转移到了未染色的姐妹染色单体上。

姐妹单体交换的原因尚不清楚，但它是必需的，并用于许多产品的突变原测试。每次有丝分裂每对染色体发生4 - 5次姐妹单体交换为正常，而14 - 100次交换则不正常，对生物体有危险。在包括布卢姆综合征在内的疾病下，姐妹单体交换的频率会升高，根据细胞类型不同，其重组频率约为正常值的10-100倍。^[1]^[2]过于频繁的姐妹单体交换可能与肿瘤的形成有关。

参见

参考文献

^ Langlois, R. G.; Bigbee, W. L.; Jensen, R. H.; German, J. Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.. Proc Natl Acad Sci U S A. Jan 1989, 86 (2): 670–4. Bibcode:1989PNAS...86..670L. PMC 286535  . PMID 2911598. doi:10.1073/pnas.86.2.670  .
^ Kusunoki, Yoichiro; Hayashi, Tomonori; Hirai, Yuko; Kushiro, Jun-Ichi; Tatsumi, Kouichi; Kurihara, Takayuki; Zghal, Mohamed; Kamoun, Mohamed R.; Takebe, Hiraku; Jeffreys, Alec; Nakamura, Nori; Akiyama, Mitoshi. Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus.. Jpn J Cancer Res. Jun 1994, 85 (6): 610–8. PMC 5919530  . PMID 8063614. doi:10.1111/j.1349-7006.1994.tb02403.x.

[1] Langlois, R. G.; Bigbee, W. L.; Jensen, R. H.; German, J. Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.. Proc Natl Acad Sci U S A. Jan 1989, 86 (2): 670–4. Bibcode:1989PNAS...86..670L. PMC 286535  . PMID 2911598. doi:10.1073/pnas.86.2.670  .

[2] Kusunoki, Yoichiro; Hayashi, Tomonori; Hirai, Yuko; Kushiro, Jun-Ichi; Tatsumi, Kouichi; Kurihara, Takayuki; Zghal, Mohamed; Kamoun, Mohamed R.; Takebe, Hiraku; Jeffreys, Alec; Nakamura, Nori; Akiyama, Mitoshi. Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus.. Jpn J Cancer Res. Jun 1994, 85 (6): 610–8. PMC 5919530  . PMID 8063614. doi:10.1111/j.1349-7006.1994.tb02403.x.

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