姊妹染色單體交換

姊妹染色單體交換（英語：sister chromatid exchange，縮寫 SCE），是兩條相同的姊妹染色單體之間的遺傳物質交換。

這是在有絲分裂後期之前，利用吉姆薩染色法在一條屬於姊妹染色單體複合物的染色單體上首次發現的。染色顯示，少數染色的片段轉移到了未染色的姊妹染色單體上。

姊妹單體交換的原因尚不清楚，但它是必需的，並用於許多產品的突變原測試。每次有絲分裂每對染色體發生4 - 5次姊妹單體交換為正常，而14 - 100次交換則不正常，對生物體有危險。在包括布盧姆綜合症在內的疾病下，姊妹單體交換的頻率會升高，根據細胞類型不同，其重組頻率約為正常值的10-100倍。^[1]^[2]過於頻繁的姊妹單體交換可能與腫瘤的形成有關。

參見

參考文獻

^ Langlois, R. G.; Bigbee, W. L.; Jensen, R. H.; German, J. Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.. Proc Natl Acad Sci U S A. Jan 1989, 86 (2): 670–4. Bibcode:1989PNAS...86..670L. PMC 286535  . PMID 2911598. doi:10.1073/pnas.86.2.670  .
^ Kusunoki, Yoichiro; Hayashi, Tomonori; Hirai, Yuko; Kushiro, Jun-Ichi; Tatsumi, Kouichi; Kurihara, Takayuki; Zghal, Mohamed; Kamoun, Mohamed R.; Takebe, Hiraku; Jeffreys, Alec; Nakamura, Nori; Akiyama, Mitoshi. Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus.. Jpn J Cancer Res. Jun 1994, 85 (6): 610–8. PMC 5919530  . PMID 8063614. doi:10.1111/j.1349-7006.1994.tb02403.x.

[1] Langlois, R. G.; Bigbee, W. L.; Jensen, R. H.; German, J. Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.. Proc Natl Acad Sci U S A. Jan 1989, 86 (2): 670–4. Bibcode:1989PNAS...86..670L. PMC 286535  . PMID 2911598. doi:10.1073/pnas.86.2.670  .

[2] Kusunoki, Yoichiro; Hayashi, Tomonori; Hirai, Yuko; Kushiro, Jun-Ichi; Tatsumi, Kouichi; Kurihara, Takayuki; Zghal, Mohamed; Kamoun, Mohamed R.; Takebe, Hiraku; Jeffreys, Alec; Nakamura, Nori; Akiyama, Mitoshi. Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus.. Jpn J Cancer Res. Jun 1994, 85 (6): 610–8. PMC 5919530  . PMID 8063614. doi:10.1111/j.1349-7006.1994.tb02403.x.

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