尿激酶受体

尿激酶受体
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1YWH、2FD6、3BT1、3BT2、3U73、3U74、2I9B、4K24、4QTI
识别号
别名	PLAUR；, CD87, U-PAR, UPAR, URKR, plasminogen activator, urokinase receptor
外部ID	OMIM：173391 MGI：97612 HomoloGene：48120 GeneCards：PLAUR
基因位置（人类）
染色体	19号染色体
终止	43,670,547 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	24,175,393 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• protein domain specific binding; • 血浆蛋白结合; • urokinase plasminogen activator receptor activity; • 酶结合; • signaling receptor binding; • signaling receptor activity;
细胞组分	• integral component of membrane; • cell projection; • endoplasmic reticulum lumen; • endoplasmic reticulum membrane; • 膜; • 粘着斑; • integral component of plasma membrane; • 细胞外区域; • 细胞连接; • anchored component of membrane; • 外排体; • extrinsic component of membrane; • 细胞膜; • specific granule membrane; • cell surface;
生物学过程	• positive regulation of protein phosphorylation; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • 纤溶作用; • negative regulation of intrinsic apoptotic signaling pathway; • urokinase plasminogen activator signaling pathway; • negative regulation of apoptotic process; • 凝血; • 糖基磷脂酰肌醇化; • 趋化性; • positive regulation of release of cytochrome c from mitochondria; • positive regulation of DNA binding; • positive regulation of epidermal growth factor receptor signaling pathway; • regulation of proteolysis; • 信号转导; • neutrophil degranulation;
	Sources:Amigo / QuickGO
直系同源
	5329
	18793
	ENSG00000011422
	ENSMUSG00000046223
	Q03405
	P35456
	NM_001005376; NM_001005377; NM_001301037; NM_002659
	NM_011113
	NP_001005376; NP_001005377; NP_001287966; NP_002650
	NP_035243
	维基数据
查看/编辑人类	查看/编辑小鼠

尿激酶受体（英语：Urokinase receptor，或称为尿纤溶酶原激活物受体，缩写uPAR,也称为CD87，Cluster of Differentiation 87，分化簇87）是一种多结构域糖蛋白，通过糖磷脂酰肌醇（GPI）锚定在细胞膜上，最初被鉴定为尿激酶（尿纤溶酶原激活物，uPA）在细胞表面的饱和结合位点。uPAR在多种癌细胞表明都有发现^[5]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000011422 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000046223 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith, HW; Marra, P; Marshall, CJ. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.. The Journal of cell biology. 2008-08-25, 182 (4): 777–90. PMID 18725541. doi:10.1083/jcb.200712050.

外部链接

医学主题词表（MeSH）：PLAUR+protein,+human
PDB中UniProt可用的所有结构信息之概述：Q03405 (Human Urokinase plasminogen activator surface receptor) 在PDBe-KB（英语：PDBe-KB）。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000011422 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000046223 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Smith, HW; Marra, P; Marshall, CJ. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.. The Journal of cell biology. 2008-08-25, 182 (4): 777–90. PMID 18725541. doi:10.1083/jcb.200712050.

[5]

[1]

[2]

[3]

[4]