溴朵林

化合物

溴朵林(U-47931E)[1]是一种有机化合物,化学式为C15H21BrN2O,它是Upjohn公司于1970年代研发[2]的对μ-阿片受体具有选择性的类阿片镇痛药[3]其药效介于可待因和吗啡之间,略强于喷他佐辛[4]

溴朵林
临床资料
其他名称Bromadoline
ATC码
  • 未分配
识别信息
  • 4-bromo-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]benzamide
CAS号67579-24-2  checkY
PubChem CID
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C15H21BrN2O
摩尔质量325.25 g·mol−1
3D模型(JSmol英语JSmol
  • CN(C)[C@@H]1CCCC[C@H]1NC(=O)C2=CC=C(C=C2)Br
  • InChI=1S/C15H21BrN2O/c1-18(2)14-6-4-3-5-13(14)17-15(19)11-7-9-12(16)10-8-11/h7-10,13-14H,3-6H2,1-2H3,(H,17,19)/t13-,14-/m1/s1
  • Key:UFDJFJYMMIZKLG-ZIAGYGMSSA-N

参见

编辑

参考文献

编辑
  1. ^ Unlisted Drugs 34–35. Chatham: Pharmaceutical Section, Special Libraries Association. 1982: 392. ISBN 978-0-913210-13-0. 
  2. ^ Jacob Szmuszkovicz. Patent US4098904 - Analgesic N-(2-aminocycloaliphatic)benzamides. The Upjohn Company. 4 July 1978 [2023-09-22]. (原始内容存档于2016-10-26). 
  3. ^ Hayes AG, Skingle M, Tyers MB. Evaluation of the receptor selectivities of opioid drugs by investigating the block of their effect on urine output by beta-funaltrexamine. The Journal of Pharmacology and Experimental Therapeutics. March 1987, 240 (3): 984–8. PMID 3559988. 
  4. ^ Hayes AG, Sheehan MJ, Tyers MB. Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to mu- and kappa-opioid receptor agonists. British Journal of Pharmacology. August 1987, 91 (4): 823–32. PMC 1853585 . PMID 2822190. doi:10.1111/j.1476-5381.1987.tb11281.x.