类固醇生成酶

类固醇生成酶类(英语:Steroidogenic enzymes)是指一大类涉及甾体激素生物合成与代谢的[2][3][4][5]。这些酶参与合成的甾体激素包括性激素类(雄激素雌激素孕激素)和肾上腺皮质激素类(糖皮质激素盐皮质激素,以及由胆固醇生成的神经甾体[3][4][5]。类固醇生成酶在涉及类固醇生成的组织,如睾丸卵巢肾上腺皮质里有很高的表达,但也存在于身体的其他组织[3][4][5]

甾体激素生物合成[1]

类固醇生成酶类列表

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甾体激素各个碳原子的编号

另见

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参考文献

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  1. ^ Häggström, Mikael; Richfield, David. Diagram of the pathways of human steroidogenesis. WikiJournal of Medicine. [2019-06-28]. doi:10.15347/wjm/2014.005. (原始内容存档于2021-02-28) (英语). 
  2. ^ Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology. Dec 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5. 
  3. ^ 3.0 3.1 3.2 Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr. Rev. 2004, 25 (6): 947–70. PMID 15583024. doi:10.1210/er.2003-0030. 
  4. ^ 4.0 4.1 4.2 Luu-The V, Labrie F. The intracrine sex steroid synthesis pathways. Prog. Brain Res. 2010, 181: 177–92. PMID 20478438. doi:10.1016/S0079-6123(08)81010-2. 
  5. ^ 5.0 5.1 5.2 Honour JW. Diagnosis of diseases of steroid hormone production, metabolism and action. J Clin Res Pediatr Endocrinol. 2009, 1 (5): 209–26. PMC 3005746 . PMID 21274298. doi:10.4274/jcrpe.v1i5.209. 
  6. ^ Guillemette C, Lévesque E, Harvey M, Bellemare J, Menard V. UGT genomic diversity: beyond gene duplication. Drug Metab. Rev. 2010, 42 (1): 24–44. PMID 19857043. doi:10.3109/03602530903210682. 
  7. ^ William Fishman. Metabolic Conjugation and Metabolic Hydrolysis, Volume II. Elsevier. 2 December 2012: 1–. ISBN 978-0-323-14308-0. 
  8. ^ 8.0 8.1 Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA. The Regulation of Steroid Action by Sulfation and Desulfation. Endocr. Rev. 2015, 36 (5): 526–63. PMC 4591525 . PMID 26213785. doi:10.1210/er.2015-1036.