类视紫红质受体

类视紫红质受体,又可译作视紫红质样受体类视紫质受体(英语:Rhodopsin-like receptors),是一个G蛋白偶联受体蛋白超家族下成员最多的蛋白家族[2],因都具有与视紫红质(视紫质)相似的由七个α螺旋组成的穿结构而得名[3][4][5]

类视紫红质受体
视紫红质的结构[1]
鉴定
标志7tm_1
PfamPF00001旧版
Pfam宗系GPCR_A旧版
InterPro英语InterProIPR000276
PROSITE英语PROSITEPDOC00211
SCOP英语Structural Classification of Proteins1f88 / SUPFAM
OPM英语Orientations of Proteins in Membranes database家族6
OPM英语Orientations of Proteins in Membranes database蛋白1gzm
CDD英语Conserved Domain Databasecd00637

类视紫红质受体下有19个亚家族[6]

参考文献

编辑
  1. ^ Palczewski K, Kumasaka T, Hori T, et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science. August 2000, 289 (5480): 739–45. Bibcode:2000Sci...289..739P. PMID 10926528. doi:10.1126/science.289.5480.739. 
  2. ^ Attwood TK, Findlay JB. Fingerprinting G-protein-coupled receptors. Protein Eng. 1994, 7 (2): 195–203. PMID 8170923. doi:10.1093/protein/7.2.195. 
  3. ^ Birnbaumer L. G proteins in signal transduction. Annu. Rev. Pharmacol. Toxicol. 1990, 30: 675–705. PMID 2111655. doi:10.1146/annurev.pa.30.040190.003331. 
  4. ^ Gilman AG, Casey PJ. G protein involvement in receptor-effector coupling. J. Biol. Chem. 1988, 263 (6): 2577–2580. PMID 2830256. 
  5. ^ Attwood TK, Findlay JB. Design of a discriminating fingerprint for G-protein-coupled receptors. Protein Eng. 1993, 6 (2): 167–176. PMID 8386361. doi:10.1093/protein/6.2.167. 
  6. ^ Joost P, Methner A. Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biol. 2002, 3 (11): research0063.1–0063.16. PMC 133447 . PMID 12429062. doi:10.1186/gb-2002-3-11-research0063.