羟甲基戊二酸单酰辅酶A还原酶 (NADPH)
羟甲基戊二酸单酰辅酶A还原酶 (NADPH)(英语:hydroxymethylglutaryl-CoA reductase (NADPH),EC 1.1.1.34 (页面存档备份,存于互联网档案馆))是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应:
羟甲基戊二酸单酰辅酶A还原酶 (NADPH) | |||||||||
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羟甲基戊二酸单酰辅酶A还原酶晶体结构(PDB 1dq8)[1] | |||||||||
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识别码 | |||||||||
EC编号 | 1.1.1.34 | ||||||||
CAS号 | 9028-35-7 | ||||||||
数据库 | |||||||||
IntEnz | IntEnz浏览 | ||||||||
BRENDA | BRENDA入口 | ||||||||
ExPASy | NiceZyme浏览 | ||||||||
KEGG | KEGG入口 | ||||||||
MetaCyc | 代谢路径 | ||||||||
PRIAM | 概述 | ||||||||
PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
基因本体 | AmiGO / EGO | ||||||||
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- (R)-甲羟戊酸 + CoA + 2 NADP+ (S)-3-羟基-3-甲基戊二酰辅酶A + 2 NADPH + 2 H+
羟甲基戊二酸单酰辅酶A还原酶 (NADPH)主要参与诸如胆固醇等类固醇的合成。用于降低胆固醇的他汀类药物通过抑制这种酶来发挥作用。
参考文献
编辑- ^ Istvan, E.S., Palnitkar, M., Buchanan, S.K., Deisenhofer, J. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J. 2000, 19: 819–830 [2012-06-03]. PMID 10698924. doi:10.1093/emboj/19.5.819. PMCID PMC305622. (原始内容存档于2014-04-07).
- Bucher NLR, Overath P and Lynen F. beta-Hydroxy-beta-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver. Biochim. Biophys. Acta. 1960, 40: 491–501. PMID 13805544. doi:10.1016/0006-3002(60)91390-1.
- DURR IF, RUDNEY H. The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid. J. Biol. Chem. 1960, 235: 2572–8. PMID 13818862.
- Kawachi T, Rudney H. Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver. Biochemistry. 1970, 9 (8): 1700–5. PMID 4985697. doi:10.1021/bi00810a008.