羟甲基戊二酸单酰辅酶A还原酶 (NADPH)

此条目介绍的是NADP⁺为受体的酶。关于同名但以NAD⁺为受体的酶，请见“羟甲基戊二酸单酰辅酶A还原酶”。

羟甲基戊二酸单酰辅酶A还原酶 (NADPH)（英语：hydroxymethylglutaryl-CoA reductase (NADPH)，EC 1.1.1.34 （页面存档备份，存于互联网档案馆））是一种以NAD⁺或NADP⁺为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：

羟甲基戊二酸单酰辅酶A还原酶 (NADPH)
羟甲基戊二酸单酰辅酶A还原酶晶体结构（PDB 1dq8）
命名 系统命名 (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating) 缩写 别名 hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase; β-hydroxy-β-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl CoA reductase (NADPH); S-3-hydroxy-3-methylglutaryl-CoA reductase; NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH2)
识别码
EC编号	1.1.1.34
CAS号	9028-35-7
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本体	AmiGO / EGO
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(R)-甲羟戊酸 + CoA + 2 NADP⁺ $\rightleftharpoons$ (S)-3-羟基-3-甲基戊二酰辅酶A + 2 NADPH + 2 H⁺

羟甲基戊二酸单酰辅酶A还原酶 (NADPH)主要参与诸如胆固醇等类固醇的合成。用于降低胆固醇的他汀类药物通过抑制这种酶来发挥作用。

参考文献

• Bucher NLR, Overath P and Lynen F. beta-Hydroxy-beta-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver. Biochim. Biophys. Acta. 1960, 40: 491–501. PMID 13805544. doi:10.1016/0006-3002(60)91390-1. 
• DURR IF, RUDNEY H. The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid. J. Biol. Chem. 1960, 235: 2572–8. PMID 13818862. 
• Kawachi T, Rudney H. Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver. Biochemistry. 1970, 9 (8): 1700–5. PMID 4985697. doi:10.1021/bi00810a008.