胱天蛋白酶5

CASP5
识别号
别名	CASP5；, ICE(rel)III, ICEREL-III, ICH-3, caspase 5
外部ID	OMIM：602665 MGI：107700 HomoloGene：129949 GeneCards：CASP5
基因位置（人类）
染色体	11号染色体
终止	105,023,168 bp
基因位置（小鼠）
染色体	小鼠9号染色体
终止	5,336,783 bp
基因本体
分子功能	• 肽酶活性; • 半胱氨酸型肽酶活性; • 水解酶活性; • scaffold protein binding; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity involved in apoptotic process; • cysteine-type endopeptidase activity; • cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • 血浆蛋白结合;
细胞组分	• NLRP3 inflammasome complex; • AIM2 inflammasome complex; • IPAF inflammasome complex; • NLRP1 inflammasome complex; • soma; • neuron projection; • 细胞质;
生物学过程	• regulation of apoptotic process; • ectopic germ cell programmed cell death; • cellular response to mechanical stimulus; • substantia nigra development; • 细胞焦亡; • 蛋白酶解; • regulation of inflammatory response; • 细胞凋亡; • execution phase of apoptosis; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • apoptotic signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	838
	12363
	ENSG00000137757
	ENSMUSG00000033538
	P51878
	P70343
	NM_001136109; NM_001136110; NM_001136112; NM_004347
	NM_007609
	NP_001129581; NP_001129582; NP_001129584; NP_004338
NP_031635; NP_001366247; NP_001366248; NP_001366249; NP_001366250;
	NP_001366251; NP_001366252
	维基数据
查看/编辑人类	查看/编辑小鼠

胱天蛋白酶5（英语：Caspase 5）是一种在人类中由CASP5基因编码的酶，属于胱天蛋白酶家族。该酶是一种在天冬氨酸残基处以蛋白水解方式裂解其他蛋白质的酶。该酶与胱天蛋白酶1、4以及鼠同源物胱天蛋白酶11一样，都是一种炎性胱天蛋白酶，在免疫系统中发挥作用。^[5]

参见

蛋白酶解图谱（英语：The Proteolysis Map）
胱天蛋白酶

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000137757 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000033538 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007, 14 (1): 10–22. PMID 16977329. doi:10.1038/sj.cdd.4402038  .

外部链接

肽酶及其抑制剂的MEROPS在线数据库：C14.008^{[失效链接]}

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000137757 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000033538 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007, 14 (1): 10–22. PMID 16977329. doi:10.1038/sj.cdd.4402038  .

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