金胺O

化合物

金胺O是一种二芳基甲烷萤光染料,常态下为黄色针状结晶。极易溶于水,易溶于乙醇

Auramine O
IUPAC名
bis[4-(dimethylamino)phenyl]methaniminium chloride
别名 Basic yellow 2, Pyocatanium aureum, aizen auramine, Pyoktanin Yellow, Canary Yellow, Pyoktanin, or C.I. 41000
识别
CAS号 2465-27-2  checkY
PubChem 17170
ChemSpider 16254
SMILES
 
  • [N@H]=C(c1ccc(N(C)C)cc1)c2ccc(N(C)C)cc2
InChI
 
  • 1/C17H21N3/c1-19(2)15-9-5-13(6-10-15)17(18)14-7-11-16(12-8-14)20(3)4/h5-12,18H,1-4H3
InChIKey JPIYZTWMUGTEHX-UHFFFAOYAY
性质
化学式 C17H22ClN3
摩尔质量 303.83 g·mol−1
熔点 267 °C
危险性
警示术语 R:R22 R24 R40
安全术语 S:S36/37 S45
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

金胺O可用于抗酸细菌(例如Mycobacterium), 其方法类似抗酸染色法。[1] 也被当做希夫试剂的萤光版来使用。[2]

金胺-若丹明染色法中与若丹明B一起用来给结核杆菌染色。[3][4] 同时也可用作防腐剂

参考文献

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  1. ^ Kommareddi S, Abramowsky C, Swinehart G, Hrabak L. Nontuberculous mycobacterial infections: comparison of the fluorescent auramine-O and Ziehl-Neelsen techniques in tissue diagnosis. Hum Pathol. 1984, 15 (11): 1085–9. PMID 6208117. doi:10.1016/S0046-8177(84)80253-1. 
  2. ^ Khavkin T, Kudryavtseva M, Dragunskaya E, Polotsky Y, Kudryavtsev B. Fluorescent PAS-reaction study of the epithelium of normal rabbit ileum and after challenge with enterotoxigenic Escherichia coli. Gastroenterology. 1980, 78 (4): 782–90. PMID 6986320. 
  3. ^ Truant J, Brett W, Thomas W. Fluorescence microscopy of tubercle bacilli stained with auramine and rhodamine. Henry Ford Hosp Med Bull. 1962, 10: 287–96. PMID 13922644. 
  4. ^ Arrowood M, Sterling C. Comparison of conventional staining methods and monoclonal antibody-based methods for Cryptosporidium oocyst detection. J Clin Microbiol. 1989, 27 (7): 1490–5. PMC 267601 . PMID 2475523. 

外部链接

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