阿马地酮

化合物
(重定向自19-去甲氯地孕酮

阿马地酮INN:amadinone)也称为19-去甲氯地孕酮,是19-去甲孕酮17α-羟孕酮组的甾体孕激素英语Progestogen (medication),于1968年合成并表征,但从未上市。[1][2]它具有抗促性腺激素英语Antigonadotropin特性,因此是一种功能性抗雄激素[3][4]该化合物还还存在一种乙酸酯,即乙酸阿马地酮,但同样从未上市。[1]

阿马地酮
临床资料
其他名称6-氯-17α-羟基-19-去甲孕-4,6-二酮
识别信息
  • (1S,2R,10R,11S,14R,15S)-14-acetyl-8-chloro-14-hydroxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-6,8-dien-5-one
CAS号30781-27-2
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C20H25ClO3
摩尔质量348.87 g·mol−1
3D模型(JSmol英语JSmol
  • CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)CC[C@H]34)Cl)C)O
  • InChI=1S/C20H25ClO3/c1-11(22)20(24)8-6-17-15-10-18(21)16-9-12(23)3-4-13(16)14(15)5-7-19(17,20)2/h9-10,13-15,17,24H,3-8H2,1-2H3/t13-,14-,15-,17+,19+,20+/m1/s1
  • Key:ANJGIFXUFSBZPX-WLCXVKOPSA-N

参考资料

编辑
  1. ^ 1.0 1.1 Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 35–. ISBN 978-1-4757-2085-3. 
  2. ^ William Andrew Publishing. Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. 22 October 2013: 206–. ISBN 978-0-8155-1856-3. 
  3. ^ Hughes A, Hasan SH, Oertel GW, Voss HE, Bahner F, Neumann G, Steinbeck H, Gräf KJ, Brotherton J, Horn HJ, Wagner RK. Androgens II and Antiandrogens / Androgene II und Antiandrogene. Springer Science & Business Media. 27 November 2013: 495–. ISBN 978-3-642-80859-3. 
  4. ^ Kent JR, Hill M, Huix FJ, Segre EJ. Seminal acid phosphatase content in the clinical bioassay of androgens and antiandrogens. Clinical Pharmacology and Therapeutics. 1972, 13 (2): 205–11. PMID 5017374. S2CID 40886901. doi:10.1002/cpt1972132205.