2000年美国职棒大联盟球季是美国联盟和国家联盟共同存在后的第100个赛季。该年的世界大赛由洋基4胜1败击败大都会,拿下世界大赛三连霸。这也是大联盟截至2021年止,最后一次出现世界大赛连霸。
这年大联盟一共出现5693支本垒打,再次刷新纪录。同时这年也是大联盟继1989年来首次没有出现无安打比赛,也没有任何球队拿下100胜。
以往大联盟美联和国联的主审是分开进行执法的,不过大联盟在这年进行整合,不论哪个联盟的主审都可以跨联盟进行执法。
- 3月29日,小熊队在东京巨蛋进行开幕战,这是大联盟首次在北美地区以外进行例行赛。[31]
- 4月3日,大联盟首次出现5人在开幕战达成双响炮。[32]
- 4月9日,双城队的Ron Coomer、Jacque Jones和Matthew LeCroy完成背靠背靠背开轰,不过皇家队的卡洛斯·贝尔川、杰梅恩·戴伊和Mike Sweeney也在同场比赛完成此成就,为大联盟头一遭。[34]
- 4月30日,红雀队单月共敲出55轰,写下大联盟纪录。[38]
- 5月11日,酿酒人队和小熊队进行了一场长达4小时22分钟的比赛,写下国联正规9局比赛的最长时间纪录。[40]
- 5月19日,海盗队的捕手Jason Kendall成为队史首位达成完全打击的选手。[42]
- 5月29日,运动家队的二垒手Randy Velarde策动独力三杀,为大联盟史上第11人。[44]
- 6月16日,在出现3次守备失误后,洋基队的二垒手Chuck Knoblauch主动退场,甚至在比赛进行中就离开球场。[54]
- 7月6日,红雀队的Keith McDonald成为史上第二位在生涯前2个打席都开轰的球员。[59]
- 7月20日,红人队的Mike Bell登上大联盟,Bell家族也成为大联盟首个祖孙3代都是大联盟选手的家族。[60][61][62]
- 8月4日,外野手Dave Martinez加入蓝鸟队,成为大联盟史上第9位同一年加入四支不同球队的选手。
- 8月19日,洋基队单局敲出3支高飞牺牲打,追平大联盟纪录。同天,太空人队的杰夫·巴格威尔成为队史首位达成生涯300轰的打者。
- 9月3日,印地安人队的Kenny Lofton连续18场比赛在首局得分,刷新大联盟纪录。
- 9月4日,红袜队的Carl Everett成为大联盟史上第6位在两联盟都打回单季100分打点的左右开弓打者。
- 9月6日,游骑兵队的Scott Sheldon成为大联盟第三位于单一比赛在9个不同守位都有守备纪录的选手。
- 9月10日,响尾蛇队的蓝迪·强森投出生涯第3000次三振。
- 9月12日,道奇队的Dave Hansen敲出单季第七发代打本垒打,刷新大联盟单季代打本垒打纪录。
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