A20 (基因)

位於6號人類染色體的基因

A20基因(或称为:肿瘤坏死因子α诱导蛋白3,英语:Tumor necrosis factor, alpha-induced protein 3,缩写TNFAIP3)是人类六号染色体上的基因[6][7],可由肿瘤坏死因子α(TNF-α)诱导表达,是一种去泛素化酶锌指蛋白,可抑制NF-κB激活和TNF介导的细胞凋亡。A20是一种非常古老的蛋白,在刺胞动物门(水母)中也有带有同源结构域的蛋白[8]

A20
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名TNFAIP3;, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
外部IDOMIM191163 MGI1196377 HomoloGene4582 GeneCardsTNFAIP3
相关疾病
红斑性狼疮、​银屑病[1]
基因位置(人类
6号染色体
染色体6号染色体[2]
6号染色体
A20的基因位置
A20的基因位置
基因座6q23.3起始137,867,214 bp[2]
终止137,883,312 bp[2]
RNA表达模式


查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_001270507
​NM_001270508
​NM_006290

NM_001166402
​NM_009397

蛋白序列

NP_001257436
​NP_001257437
​NP_006281

NP_001159874
​NP_033423

基因位置​(UCSC)Chr 6: 137.87 – 137.88 MbChr 10: 18.88 – 18.89 Mb
PubMed​查找[4][5]
维基数据
查看/编辑人类查看/编辑小鼠

蛋白质的相互作用

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A20蛋白与下列蛋白质进行互作TNIP1[9]TRAF1[10][11]TRAF2[10]IKBKG[12]TAX1BP1[13]YWHAB[14]YWHAZ[14][15]TRAF6[11][16]YWHAH[14][15]

参考文献

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  1. ^ 與A20相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Opipari AW Jr; Boguski MS; Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515. 
  7. ^ Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3. (原始内容存档于2010-12-05). 
  8. ^ Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions. Frontiers in Immunology. 2018, 9: 1136. PMC 5978004 . PMID 29881386. doi:10.3389/fimmu.2018.01136. 
  9. ^ Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159 . PMID 10385526. doi:10.1083/jcb.145.7.1471. 
  10. ^ 10.0 10.1 Song, H Y; Rothe M; Goeddel D V. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721. 
  11. ^ 11.0 11.1 Heyninck, K; Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7. 
  12. ^ Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1. 
  13. ^ De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787 . 
  14. ^ 14.0 14.1 14.2 Vincenz, C; Dixit V M. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029 . 
  15. ^ 15.0 15.1 De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343. 
  16. ^ Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. Isolation and characterization of two novel A20-like proteins. Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617. 

外部链接

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