BRL-37344

**BRL-37344**
临床资料
商品名（英语：Drug nomenclature）	BRL-37344
法律规范状态
法律规范	美：Investigational New Drug;
识别信息
	IUPAC命名法 2-{4-[(2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl]phenoxy}acetic acid; ;
CAS号	114333-71-0
PubChem CID	9841972;
化学信息
化学式	C19H22ClNO4
摩尔质量	363.8
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C[C@H](CC1=CC=C(C=C1)OCC(=O)O)NC[C@@H](C2=CC(=CC=C2)Cl)O;
	InChI InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1; Key:ZGGNJJJYUVRADP-ACJLOTCBSA-N;

BRL-37344是一种药物，分子式C₁₉H₂₂ClNO₄，为β-3肾上腺素（英语：Beta-3 adrenergic receptor）受体选择性激动剂，^[1]已针对各种生物医学的应用开展了相关研究，但尚未提供临床使用。^[2]^[3]^[4]^[5]^[6]^[7]

参考文献编辑

^ Bond RA, Clarke DE. Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes. British Journal of Pharmacology. November 1988, 95 (3): 723–34. PMC 1854239  . PMID 2905184. doi:10.1111/j.1476-5381.1988.tb11698.x.
^ Napp A, Brixius K, Pott C, Ziskoven C, Boelck B, Mehlhorn U, et al. Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium. Journal of Cardiac Failure. February 2009, 15 (1): 57–67. PMID 19181295. doi:10.1016/j.cardfail.2008.08.006.
^ Afeli SA, Rovner ES, Petkov GV. BRL37344, a β3-adrenergic receptor agonist, decreases nerve-evoked contractions in human detrusor smooth muscle isolated strips: role of BK channels. Urology. September 2013, 82 (3): 744.e1–7. PMC 3758792  . PMID 23890664. doi:10.1016/j.urology.2013.05.027.
^ Maryanovich M, Zahalka AH, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nature Medicine. June 2018, 24 (6): 782–791. PMC 6095812  . PMID 29736022. doi:10.1038/s41591-018-0030-x.
^ Xu Z, Wu J, Xin J, Feng Y, Hu G, Shen J, et al. β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway. Biochemical and Biophysical Research Communications. September 2018, 503 (1): 146–151. PMID 29859189. doi:10.1016/j.bbrc.2018.05.200.
^ Grzelka K, Gawlak M, Czarzasta K, Szulczyk P. β3-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats. Neuroscience Letters. April 2019, 698: 192–197. PMID 30641111. doi:10.1016/j.neulet.2019.01.022.
^ Fellous TG, Redpath AN, Fleischer MM et al. Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery. npj Regen Med 2020; 5: 3. doi:10.1038/s41536-020-0088-1

这是一篇与药学相关的小作品。你可以通过编辑或修订扩充其内容。

[1] Bond RA, Clarke DE. Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes. British Journal of Pharmacology. November 1988, 95 (3): 723–34. PMC 1854239  . PMID 2905184. doi:10.1111/j.1476-5381.1988.tb11698.x.

[2] Napp A, Brixius K, Pott C, Ziskoven C, Boelck B, Mehlhorn U, et al. Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium. Journal of Cardiac Failure. February 2009, 15 (1): 57–67. PMID 19181295. doi:10.1016/j.cardfail.2008.08.006.

[3] Afeli SA, Rovner ES, Petkov GV. BRL37344, a β3-adrenergic receptor agonist, decreases nerve-evoked contractions in human detrusor smooth muscle isolated strips: role of BK channels. Urology. September 2013, 82 (3): 744.e1–7. PMC 3758792  . PMID 23890664. doi:10.1016/j.urology.2013.05.027.

[4] Maryanovich M, Zahalka AH, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nature Medicine. June 2018, 24 (6): 782–791. PMC 6095812  . PMID 29736022. doi:10.1038/s41591-018-0030-x.

[5] Xu Z, Wu J, Xin J, Feng Y, Hu G, Shen J, et al. β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway. Biochemical and Biophysical Research Communications. September 2018, 503 (1): 146–151. PMID 29859189. doi:10.1016/j.bbrc.2018.05.200.

[6] Grzelka K, Gawlak M, Czarzasta K, Szulczyk P. β3-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats. Neuroscience Letters. April 2019, 698: 192–197. PMID 30641111. doi:10.1016/j.neulet.2019.01.022.

[7] Fellous TG, Redpath AN, Fleischer MM et al. Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery. npj Regen Med 2020; 5: 3. doi:10.1038/s41536-020-0088-1

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BRL-37344

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参考文献编辑