CD14

CD14
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4GLP
识别号
别名	CD14；, entrez:929, CD14 molecule
外部ID	OMIM：158120 MGI：88318 HomoloGene：493 GeneCards：CD14
基因位置（人类）
染色体	5号染色体
终止	140,633,700 bp
基因位置（小鼠）
染色体	小鼠18号染色体
终止	36,859,851 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• lipopolysaccharide binding; • opsonin receptor activity; • lipoteichoic acid binding; • 血浆蛋白结合; • peptidoglycan immune receptor activity; • lipopeptide binding;
细胞组分	• 高尔基体; • 膜; • 细胞膜; • 细胞外区域; • cell surface; • lipopolysaccharide receptor complex; • anchored component of external side of plasma membrane; • 脂筏模型; • anchored component of membrane; • endosome membrane; • 外排体; • external side of plasma membrane; • 细胞外空间; • secretory granule membrane;
生物学过程	• toll-like receptor TLR1:TLR2 signaling pathway; • response to bacterium; • toll-like receptor 4 signaling pathway; • immune system process; • cellular response to diacyl bacterial lipopeptide; • positive regulation of interferon-gamma production; • response to magnesium ion; • response to heat; • response to electrical stimulus; • MyD88-dependent toll-like receptor signaling pathway; • 受体介导的内吞作用; • cellular response to triacyl bacterial lipopeptide; • TRIF-dependent toll-like receptor signaling pathway; • response to tumor necrosis factor; • positive regulation of endocytosis; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • cellular response to lipoteichoic acid; • 吞噬作用; • positive regulation of tumor necrosis factor production; • inflammatory response; • response to ethanol; • I-kappaB kinase/NF-kappaB signaling; • toll-like receptor TLR6:TLR2 signaling pathway; • cellular response to lipopolysaccharide; • response to molecule of bacterial origin; • positive regulation of type I interferon production; • lipopolysaccharide-mediated signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • 细胞凋亡; • 先天免疫系统; • 程序性坏死; • negative regulation of MyD88-independent toll-like receptor signaling pathway; • apoptotic signaling pathway; • toll-like receptor signaling pathway; • neutrophil degranulation; • positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
直系同源
	929
	12475
	ENSG00000170458
	ENSMUSG00000051439
	P08571
	P10810
	NM_001174105; NM_000591; NM_001040021; NM_001174104
	NM_009841
	NP_000582; NP_001035110; NP_001167575; NP_001167576
	NP_033971
	维基数据
查看/编辑人类	查看/编辑小鼠

CD14（cluster of differentiation 14，分化簇14）是一种细胞表面蛋白质，主要在先天免疫系统的巨噬细胞上表达^[5]，是最早发现的模式识别受体^[6]，能参与识别脂多糖（LPS，一种病原相关分子模式）。

参考文献编辑

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000170458 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000051439 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S. Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. July 1989, 1008 (2): 213–222. PMID 2472171. doi:10.1016/0167-4781(80)90012-3.
^ Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B. Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood. January 1989, 73 (1): 284–289. PMID 2462937. doi:10.1182/blood.V73.1.284.284  .

外部链接编辑

Human CD14 genome location and CD14 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
PDB中UniProt可用的所有结构信息之概述：P08571 (Monocyte differentiation antigen CD14) 在PDBe-KB（英语：PDBe-KB）。
医学主题词表（MeSH）：CD14+Antigens

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000170458 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000051439 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2472171-5] Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S. Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. July 1989, 1008 (2): 213–222. PMID 2472171. doi:10.1016/0167-4781(80)90012-3.

[pmid2462937-6] Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B. Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood. January 1989, 73 (1): 284–289. PMID 2462937. doi:10.1182/blood.V73.1.284.284  .

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CD14

参考文献 编辑

外部链接 编辑

参考文献编辑

外部链接编辑