CD43

CD43
识别号
别名	SPN；, CD43, GALGP, GPL115, LSN, sialophorin, LEU-22
外部ID	OMIM：182160 MGI：98384 HomoloGene：36108 GeneCards：SPN
基因位置（人类）
染色体	16号染色体
终止	29,670,876 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	126,736,995 bp
基因本体
分子功能	• transmembrane signaling receptor activity; • Hsp70 protein binding; • heat shock protein binding;
细胞组分	• integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • 基底膜; • cell surface; • 尾肢; • 外排体; • external side of plasma membrane; • 细胞外空间;
生物学过程	• negative regulation of cell adhesion; • positive regulation of protein phosphorylation; • negative regulation of type IV hypersensitivity; • response to protozoan; • T cell costimulation; • negative thymic T cell selection; • 趋化性; • establishment or maintenance of cell polarity; • cellular defense response; • cell surface receptor signaling pathway; • negative regulation of T cell proliferation; • defense response to bacterium; • 免疫反应; • positive regulation of T cell proliferation; • regulation of immune response; • apoptotic signaling pathway; • regulation of defense response to virus; • negative regulation of T cell activation; • leukocyte migration; • 信号转导;
	Sources:Amigo / QuickGO
直系同源
	6693
	20737
	ENSG00000197471
	ENSMUSG00000051457
	P16150
	P15702
	NM_001030288; NM_003123
	NM_001037810; NM_009259
	NP_001025459; NP_003114
	NP_001032899; NP_033285
	维基数据
查看/编辑人类	查看/编辑小鼠

CD43（白细胞分化抗原43）又名白细胞唾液酸糖蛋白（Leukosialin）或唾液酸蛋白（sialophorin），是一种跨膜表面蛋白，在人体中由SPN（唾液蛋白）基因编码^[5]^[6]^[7]。

功能

唾液蛋白（leukosialin）是人类T淋巴细胞，单核细胞，粒细胞和一些B淋巴细胞表面的主要唾液酸糖蛋白，它们似乎对免疫功能很重要，可能是参与T细胞激活的生理性配体 - 受体复合物的一部分^[6]。

临床意义

CD43分子中的缺陷与Wiskott-Aldrich综合征的发病有关^[8]。也在大约25％的肠道MALT瘤中出现，通过免疫组织化学技术，可以在健康淋巴结和扁桃体的皮质T细胞中证实CD43的存在。CD43在一系列淋巴和骨髓肿瘤中也是阳性的。虽然它于超过90％的T细胞淋巴瘤中存在，但它在诊断这些病症方面通常不如CD3抗原有效。然而，它可以作为一系列抗原的一部分用于诊断B细胞淋巴母细胞淋巴瘤，因为在这种情况下的恶性细胞通常CD43是阳性的，并且可能难以用其他抗体染色。因为它会污染粒细胞及其前体细胞，它也是骨髓瘤的有效标记物^[9]。

相互作用

CD43已被证实与埃兹蛋白Ezrin^[10]和膜突蛋白Moesin^[11]具有相互作用。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197471 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000051457 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ SPN sialophorin [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2018-07-15]. （原始内容存档于2019-02-15）.
^ ^6.0 ^6.1 Pallant, A.; Eskenazi, A.; Mattei, M. G.; Fournier, R. E.; Carlsson, S. R.; Fukuda, M.; Frelinger, J. G. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proceedings of the National Academy of Sciences of the United States of America. 1989-2, 86 (4): 1328–1332 [2018-07-15]. ISSN 0027-8424. PMC 286683  . PMID 2521952. （原始内容存档于2018-08-20）. 请检查|date=中的日期值 (帮助)
^ Shelley, C. S.; Remold-O'Donnell, E.; Davis, A. E.; Bruns, G. A.; Rosen, F. S.; Carroll, M. C.; Whitehead, A. S. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Proceedings of the National Academy of Sciences of the United States of America. 1989-4, 86 (8): 2819–2823 [2018-07-15]. ISSN 0027-8424. PMC 287010  . PMID 2784859. （原始内容存档于2018-08-20）. 请检查|date=中的日期值 (帮助)
^ Remold-O'Donnell, E.; Rosen, F. S. Sialophorin (CD43) and the Wiskott-Aldrich syndrome. Immunodeficiency Reviews. 1990, 2 (2): 151–174 [2018-07-15]. ISSN 0893-5300. PMID 2223062. （原始内容存档于2018-07-16）.
^ 1945-2011., Leong, Anthony S.-Y. (Anthony Siew-Yin),; W.-M., Leong, F. Joel. Manual of diagnostic antibodies for immunohistology. 2nd ed. London: Greenwich Medical Media https://www.worldcat.org/oclc/51439459. 2003 [2018-07-15]. ISBN 9781841101002. OCLC 51439459. （原始内容存档于2019-09-24）. 缺少或|title=为空 (帮助)
^ Serrador, J. M.; Nieto, M.; Alonso-Lebrero, J. L.; del Pozo, M. A.; Calvo, J.; Furthmayr, H.; Schwartz-Albiez, R.; Lozano, F.; González-Amaro, R. CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Blood. 1998-06-15, 91 (12): 4632–4644 [2018-07-15]. ISSN 0006-4971. PMID 9616160. （原始内容存档于2018-07-15）.
^ Yonemura, S.; Hirao, M.; Doi, Y.; Takahashi, N.; Kondo, T.; Tsukita, S.; Tsukita, S. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. The Journal of Cell Biology. 1998-02-23, 140 (4): 885–895 [2018-07-15]. ISSN 0021-9525. PMC 2141743  . PMID 9472040. （原始内容存档于2018-07-16）.

外部链接

医学主题词表（MeSH）：CD43+antigen
Human SPN genome location and SPN gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197471 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000051457 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] SPN sialophorin [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2018-07-15]. （原始内容存档于2019-02-15）.

[:0-6] 6.0 ^6.1 Pallant, A.; Eskenazi, A.; Mattei, M. G.; Fournier, R. E.; Carlsson, S. R.; Fukuda, M.; Frelinger, J. G. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proceedings of the National Academy of Sciences of the United States of America. 1989-2, 86 (4): 1328–1332 [2018-07-15]. ISSN 0027-8424. PMC 286683  . PMID 2521952. （原始内容存档于2018-08-20）. 请检查|date=中的日期值 (帮助)

[7] Shelley, C. S.; Remold-O'Donnell, E.; Davis, A. E.; Bruns, G. A.; Rosen, F. S.; Carroll, M. C.; Whitehead, A. S. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Proceedings of the National Academy of Sciences of the United States of America. 1989-4, 86 (8): 2819–2823 [2018-07-15]. ISSN 0027-8424. PMC 287010  . PMID 2784859. （原始内容存档于2018-08-20）. 请检查|date=中的日期值 (帮助)

[8] Remold-O'Donnell, E.; Rosen, F. S. Sialophorin (CD43) and the Wiskott-Aldrich syndrome. Immunodeficiency Reviews. 1990, 2 (2): 151–174 [2018-07-15]. ISSN 0893-5300. PMID 2223062. （原始内容存档于2018-07-16）.

[9] 1945-2011., Leong, Anthony S.-Y. (Anthony Siew-Yin),; W.-M., Leong, F. Joel. Manual of diagnostic antibodies for immunohistology. 2nd ed. London: Greenwich Medical Media https://www.worldcat.org/oclc/51439459. 2003 [2018-07-15]. ISBN 9781841101002. OCLC 51439459. （原始内容存档于2019-09-24）. 缺少或|title=为空 (帮助)

[10] Serrador, J. M.; Nieto, M.; Alonso-Lebrero, J. L.; del Pozo, M. A.; Calvo, J.; Furthmayr, H.; Schwartz-Albiez, R.; Lozano, F.; González-Amaro, R. CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Blood. 1998-06-15, 91 (12): 4632–4644 [2018-07-15]. ISSN 0006-4971. PMID 9616160. （原始内容存档于2018-07-15）.

[11] Yonemura, S.; Hirao, M.; Doi, Y.; Takahashi, N.; Kondo, T.; Tsukita, S.; Tsukita, S. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. The Journal of Cell Biology. 1998-02-23, 140 (4): 885–895 [2018-07-15]. ISSN 0021-9525. PMC 2141743  . PMID 9472040. （原始内容存档于2018-07-16）.

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