多巴胺β羟化酶

多巴胺β羟化酶
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4ZEL
识别号
别名	DBH；, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP1
外部ID	OMIM：609312 MGI：94864 HomoloGene：615 GeneCards：DBH
EC number	1.14.17.1
相关疾病
	dopamine beta-hydroxylase deficiency
为以下药物的标靶
	nepicastat
基因位置（人类）
染色体	9号染色体
终止	133,659,329 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	27,073,212 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 金属离子结合; • monooxygenase activity; • oxidoreductase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen; • L-ascorbic acid binding; • 催化活性; • dopamine beta-monooxygenase activity; • copper ion binding;
细胞组分	• 细胞质; • transport vesicle membrane; • integral component of membrane; • chromaffin granule lumen; • chromaffin granule membrane; • cytoplasmic vesicle; • 膜; • 细胞外区域; • 细胞外空间; • secretory granule membrane; • secretory granule lumen; • 细胞内膜结合细胞器; • 内质网; • 微管组织中心;
生物学过程	• response to amphetamine; • 化学性突触传递; • homoiothermy; • leukocyte mediated immunity; • visual learning; • fear response; • behavioral response to ethanol; • locomotory behavior; • regulation of extrinsic apoptotic signaling pathway; • regulation of cell population proliferation; • positive regulation of vasoconstriction; • glucose homeostasis; • 母性行为; • 记忆; • leukocyte migration; • response to pain; • blood vessel remodeling; • cytokine production; • 联想型学习; • catecholamine biosynthetic process; • dopamine catabolic process; • norepinephrine biosynthetic process; • octopamine biosynthetic process; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	1621
	13166
	ENSG00000123454
	ENSMUSG00000000889
	P09172
	Q64237
	NM_000787
	NM_138942
	NP_000778
	NP_620392
	维基数据
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