HIST4H4

HIST4H4为人体中的一种编码一类组蛋白H4的基因。HIST4H4没有内含子，编码组蛋白H4家族中的一种蛋白质。HIST4H4基因对应的mRNA缺乏Poly(A)尾巴。不过，这类mRNA有一个回文终止元件。

HIST4H4
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4H9O、​3WKJ、​3AYW、​3WA9、​5B0Z、​5AVB、​2CV5、​5AV5、​3AV2、​3WTP、​3AV1、​3AZK、​3X1V、​5AV8、​1F66、​4QUU、​3CFS、​4YYK、​4QUT、​3NQJ、​3A6N、​3W99、​5AVC、​2RS9、​3F9Z、​3QZT、​3QBY、​3W97、​4M38、​4YM6、​3CFV、​4HGA、​1EQZ、​2RJE、​3QZV、​1HQ3、​4H9P、​3AZL、​3AFA、​1TZY、​3UVY、​5CPK、​3JPX、​4U9W、​4N3W、​4YYJ、​4YYD、​4H9N、​4H9R、​3AZI、​4LD9、​3UVX、​3AZH、​5BNX、​4N4F、​1U35、​4YYG、​3O36、​2ARO、​5AV9、​4H9S、​3AZF、​3W98、​4GQB、​4H9Q、​5BNV、​3WAA、​3AZG、​3AZE、​2RNY、​1ZKK、​2QQS、​2LVM、​3X1T、​3AN2、​2KWO、​3QZS、​3F9W、​5FFW、​5CPJ、​3F9X、​3IJ1、​4YM5、​3AZJ、​4YY6、​3AZN、​2IG0、​4YYH、​4YYI、​5CPI、​3W96、​3R45、​2KWN、​3F9Y、​5AV6、​3AZM、​5BO0、​3X1S、​4QYD、​4KGC、​3UVW、​4YYN、​3X1U、​3UW9、​2F8N、​3NQU、​5B0Y、​4YYM、​5C3I、​4Z5T、​5B24、​5FA5、​4Z2M、​5E5A、​5FWE、​5B2I、​5B40、​5B2J、​5JA4、​5AY8、​4ZUX
识别号
别名	H4-16；, H4/p, histone cluster 4, H4, histone cluster 4 H4, HIST4H4, H4 histone 16, H4C5, H4C4, H4C9, H4C12, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, H4C16
外部ID	OMIM：615069 MGI：2448432 HomoloGene：134468 GeneCards：H4-16
基因位置（人类） 染色体 12号染色体 基因座 12p12.3 起始 14,767,999 bp 终止 14,771,131 bp
基因位置（小鼠） 染色体 小鼠13号染色体 基因座 13|13 A3.1 起始 22,224,806 bp 终止 22,225,532 bp
基因本体 分子功能 • protein domain specific binding • 血浆蛋白结合 • protein heterodimerization activity • DNA结合 • histone binding • RNA binding 细胞组分 • 膜 • 染色体 • 核质 • 细胞外区域 • nuclear chromosome • 核小体 • 外排体 • 细胞核 • 细胞外间质 • 大分子复合体 生物学过程 • telomere organization • epigenetic maintenance of chromatin in transcription-competent conformation • protein heterotetramerization • negative regulation of megakaryocyte differentiation • CENP-A containing chromatin assembly • DNA replication-dependent chromatin assembly • rDNA heterochromatin assembly • negative regulation of gene expression, epigenetic • DNA-templated transcription, initiation • double-strand break repair via nonhomologous end joining • beta-catenin-TCF complex assembly • telomere capping • nucleosome assembly • regulation of gene silencing by miRNA • regulation of megakaryocyte differentiation • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	121504	319158
Ensembl	ENSG00000197837	ENSMUSG00000060639
UniProt	P62805	P62806
mRNA​序列	NM_175054	NM_175656
蛋白序列	NP_003537 ​NP_003486 ​NP_003535 ​NP_003539 ​NP_003531 ​NP_003536	NP_291074 ​NP_783587 ​NP_783588 ​NP_835499 ​NP_835500 ​NP_001182350 ​NP_835515 ​NP_783585 ​NP_783586 ​NP_835582 ​NP_835583 ​NP_783583 ​NP_694813
基因位置​（UCSC）	Chr 12: 14.77 – 14.77 Mb	Chr 13: 22.22 – 22.23 Mb
PubMed​查找
维基数据
查看/编辑人类 查看/编辑小鼠

拓展阅读

• Pauli U, Chrysogelos S, Stein G, et al. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene.. Science. 1987, 236 (4806): 1308–11. PMID 3035717. doi:10.1126/science.3035717. 
• Borowski P, Heiland M, Oehlmann K, et al. Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.. Eur. J. Biochem. 1996, 237 (3): 611–8. PMID 8647104. doi:10.1111/j.1432-1033.1996.0611p.x. 
• El Kharroubi A, Piras G, Zensen R, Martin MA. Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter. Mol. Cell. Biol. 1998, 18 (5): 2535–44. PMC 110633 . PMID 9566873. doi:10.1128/mcb.18.5.2535. 
• Zhang Y, Sun ZW, Iratni R, et al. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol. Cell. 1998, 1 (7): 1021–31. PMID 9651585. doi:10.1016/S1097-2765(00)80102-1. 
• Carrier F, Georgel PT, Pourquier P, et al. Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin. Mol. Cell. Biol. 1999, 19 (3): 1673–85. PMC 83961 . PMID 10022855. 
• Buggy JJ, Sideris ML, Mak P, et al. Cloning and characterization of a novel human histone deacetylase, HDAC8. Biochem. J. 2001,. 350 Pt 1 (Pt 1): 199–205. PMC 1221242 . PMID 10926844. doi:10.1042/0264-6021:3500199. 
• Deng L, de la Fuente C, Fu P, et al. Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. Virology. 2001, 277 (2): 278–95. PMID 11080476. doi:10.1006/viro.2000.0593. 
• Chadwick BP, Willard HF. A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome. J. Cell Biol. 2001, 152 (2): 375–84. PMC 2199617 . PMID 11266453. doi:10.1083/jcb.152.2.375. 
• Kovalsky O, Lung FD, Roller PP, Fornace AJ. Oligomerization of human Gadd45a protein. J. Biol. Chem. 2001, 276 (42): 39330–9. PMID 11498536. doi:10.1074/jbc.M105115200. 
• Deng L, Wang D, de la Fuente C, et al. Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. Virology. 2001, 289 (2): 312–26. PMID 11689053. doi:10.1006/viro.2001.1129. 
• Lahn BT, Tang ZL, Zhou J, et al. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (13): 8707–12. PMC 124363 . PMID 12072557. doi:10.1073/pnas.082248899. 
• Ono S, Oue N, Kuniyasu H, et al. Acetylated histone H4 is reduced in human gastric adenomas and carcinomas. J. Exp. Clin. Cancer Res. 2003, 21 (3): 377–82. PMID 12385581. 
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. 
• Kzhyshkowska J, Rusch A, Wolf H, Dobner T. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. Biochem. J. 2003, 371 (Pt 2): 385–93. PMC 1223277 . PMID 12489984. doi:10.1042/BJ20021281. 
• Fujita K, Shimazaki N, Ohta Y, et al. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. Genes Cells. 2004, 8 (6): 559–71. PMID 12786946. doi:10.1046/j.1365-2443.2003.00656.x. 
• Shiio Y, Eisenman RN. Histone sumoylation is associated with transcriptional repression. Proc. Natl. Acad. Sci. U.S.A. 2004, 100 (23): 13225–30. PMC 263760 . PMID 14578449. doi:10.1073/pnas.1735528100. 
• Coleman MA, Miller KA, Beernink PT, et al. Identification of chromatin-related protein interactions using protein microarrays. Proteomics. 2004, 3 (11): 2101–7. PMID 14595808. doi:10.1002/pmic.200300593. 
• Lusic M, Marcello A, Cereseto A, Giacca M. Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. EMBO J. 2004, 22 (24): 6550–61. PMC 291826 . PMID 14657027. doi:10.1093/emboj/cdg631. 
• Kanno T, Kanno Y, Siegel RM, et al. Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol. Cell. 2004, 13 (1): 33–43. PMID 14731392. doi:10.1016/S1097-2765(03)00482-9.