JWH-200,也称作WIN 55,225[1],是一种由约翰·威廉·霍夫曼小组合成的萘甲酰基吲哚JWH大麻素[2],分子式C25H24N2O2,可作为镇痛药使用。

JWH-200
临床资料
其他名称WIN 55,225
法律规范状态
法律规范
识别信息
  • (1-(2-Morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanone
CAS号103610-04-4  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C25H24N2O2
摩尔质量384.48 g·mol−1
3D模型(JSmol英语JSmol
  • O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(C4=C3C=CC=C4)CCN5CCOCC5
  • InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2
  • Key:SZWYXJHTNGJPKU-UHFFFAOYSA-N

参考文献

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  1. ^ Dutta AK, Ryan W, Thomas BF, Singer M, Compton DR, Martin BR, Razdan RK. Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs). Bioorganic & Medicinal Chemistry. August 1997, 5 (8): 1591–600. PMID 9313864. doi:10.1016/S0968-0896(97)00111-9. 
  2. ^ Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor. Bioorganic & Medicinal Chemistry. February 2003, 11 (4): 539–49. PMID 12538019. S2CID 29107765. doi:10.1016/S0968-0896(02)00451-0. 

外部链接

编辑