LHX2

LHX2
识别号
别名	LHX2；, LH2, hLhx2, LIM homeobox 2
外部ID	OMIM：603759 MGI：96785 HomoloGene：55848 GeneCards：LHX2
基因位置（人类）
染色体	9号染色体
终止	124,033,301 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	38,259,745 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• 金属离子结合; • sequence-specific DNA binding; • chromatin binding; • DNA结合; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA-binding transcription activator activity, RNA polymerase II-specific; • DNA-binding transcription factor activity, RNA polymerase II-specific; • 转录因子结合; • RNA polymerase II transcription regulatory region sequence-specific DNA binding;
细胞组分	• 细胞核; • 胞内;
生物学过程	• negative regulation of transcription regulatory region DNA binding; • mesoderm development; • telencephalon development; • neural tube closure; • retina development in camera-type eye; • 大脑皮质的组织发生; • transcription, DNA-templated; • 轴突导向; • axon extension; • hair follicle development; • maintenance of epithelial cell apical/basal polarity; • 神经发生; • brain development; • olfactory bulb development; • 神经系统的发育; • dorsal/ventral pattern formation; • positive regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • positive regulation of transcription by RNA polymerase II; • neuron differentiation; • anatomical structure formation involved in morphogenesis; • telencephalon regionalization; • transcription by RNA polymerase II; • negative regulation of gene expression, epigenetic; • negative regulation of neurogenesis; • positive regulation of neural precursor cell proliferation;
	Sources:Amigo / QuickGO
直系同源
	9355
	16870
	ENSG00000106689
	ENSMUSG00000000247
	P50458
	Q9Z0S2
	NM_004789
	NM_001290646; NM_010710
	NP_004780
	NP_001277575; NP_034840
	维基数据
查看/编辑人类	查看/编辑小鼠

LIM同源框蛋白质 LHX2是蛋白质的一种，在人类内由“LHX2”基因所编码。^[5]^[6]^[7]

LHX2包含LIM结构域，这是一种带有许多半胱氨酸，具锌指结构的结构域。该蛋白质的作用为转录调控。该蛋白质在果蝇体内，可用来回复由其他蛋白质引起的表型，推测是在演化时留下的功能^[7]。

交互作用

LHX2已证实会与CITED2 交互作用。^[8]

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. Oncogene. Jul 1996, 12 (6): 1205–12. PMID 8649822.
^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proc Natl Acad Sci U S A. Apr 1999, 96 (5): 2165–70. PMC 26754  . PMID 10051612. doi:10.1073/pnas.96.5.2165.
^ ^7.0 ^7.1 Entrez Gene: LHX2 LIM homeobox 2.
^ Glenn, D J; Maurer R A. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. (UNITED STATES). Dec 1999, 274 (51): 36159–67. ISSN 0021-9258. PMID 10593900. doi:10.1074/jbc.274.51.36159.

延伸阅读

Gerhard DS, Wagner L, Feingold EA et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.
Ota T, Suzuki Y, Nishikawa T et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Glenn DJ, Maurer RA. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. 2000, 274 (51): 36159–67. PMID 10593900. doi:10.1074/jbc.274.51.36159.
Bach I, Rodriguez-Esteban C, Carrière C et al. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 1999, 22 (4): 394–9. PMID 10431247. doi:10.1038/11970.
Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C. Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation. 1998, 63 (3): 151–7. PMID 9697309. doi:10.1046/j.1432-0436.1998.6330151.x.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8649822-5] Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. Oncogene. Jul 1996, 12 (6): 1205–12. PMID 8649822.

[pmid10051612-6] Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proc Natl Acad Sci U S A. Apr 1999, 96 (5): 2165–70. PMC 26754  . PMID 10051612. doi:10.1073/pnas.96.5.2165.

[entrez-7] 7.0 ^7.1 Entrez Gene: LHX2 LIM homeobox 2.

[pmid10593900-8] Glenn, D J; Maurer R A. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. (UNITED STATES). Dec 1999, 274 (51): 36159–67. ISSN 0021-9258. PMID 10593900. doi:10.1074/jbc.274.51.36159.

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