TAS2R46
位於12號人類染色體的基因
味觉感受器，类型2，成员46，TAS2R46 是一个人类基因组中TAS2R46基因编码的蛋白质，是苦味味觉感受器的一员。[1][2]
| 味觉感受器，类型2，成员46 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 标识 | |||||||||||||
| 代号 | TAS2R46; T2R46; T2R54 | ||||||||||||
| 扩展标识 | 遗传学：612774 鼠基因：2681256 同源基因：131216 IUPHAR: GeneCards: TAS2R46 Gene | ||||||||||||
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| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 259292 | 387348 | |||||||||||
| Ensembl | ENSG00000226761 | ENSMUSG00000059382 | |||||||||||
| UniProt | P59540 | Q7M721 | |||||||||||
| mRNA序列 | NM_176887 | NM_207023 | |||||||||||
| 蛋白序列 | NP_795368 | NP_996906 | |||||||||||
| 基因位置 |
Chr 12: 11.21 – 11.21 Mb |
Chr 6: 132.62 – 132.62 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
另见
编辑参考文献
编辑- ^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
- ^ Entrez Gene: TAS2R46 taste receptor, type 2, member 46.
延伸阅读
编辑- Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Zhang Y, Hoon MA, Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Conte C, Ebeling M, Marcuz A; et al. Identification and characterization of human taste receptor genes belonging to the TAS2R family.. Cytogenet. Genome Res. 2003, 98 (1): 45–53. PMID 12584440. doi:10.1159/000068546.
- Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics. 2006, 170 (1): 313–26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
