讨论:谷氨酸脱羧酶

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未翻译内容如下：--Flame 欢迎泡茶 2011年6月19日 (日) 00:28 (UTC)回复

糖尿病

Both GAD₆₇ and GAD₆₅ are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes.^[1]^[2] Injections with GAD₆₅ has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes.^[3]^[4]

精神分裂症与双相型障碍

GAD mRNA表达的大量失调，coupled with downregulation of reelin, is observed in 精神分裂症 and 双相障碍.^[5] The most pronounced downregulation of GAD67 was found in hippocampal stratum oriens layer in both disorders and in other layers and structures of hippocampus with varying degrees.^[6]

药物引起的改变

普瑞巴林，一种抗癫痫药, increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity.[1] Extracts from Centella asiatica (gotu kola) and Valeriana officinalis (valerian) stimulated GAD activity.^[7]

外部链接已修改

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各位维基人：

我刚刚修改了谷氨酸脱羧酶中的1个外部链接，请大家仔细检查我的编辑。如果您有疑问，或者需要让机器人忽略某个链接甚至整个页面，请访问这个简单的FAQ获取更多信息。我进行了以下修改：

向 http://www.schizophreniaforum.org/new/detail.asp?id=1358 中加入存档链接 https://web.archive.org/web/20070815162255/http://www.schizophreniaforum.org/new/detail.asp?id=1358

有关机器人修正错误的详情请参阅FAQ。

祝编安。—InternetArchiveBot (报告软件缺陷) 2017年7月22日 (六) 05:43 (UTC)回复

^ Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Camilli PD. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990, 347 (6289): 151–6. PMID 1697648. doi:10.1038/347151a0.
^ Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ. Autoimmunity to two forms of 谷氨酸脱羧酶 in insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89 (1): 283–92. PMC 442846  . PMID 1370298. doi:10.1172/JCI115573.
^ Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, Lindh A, Nilsson NO, Aman J, Ortqvist E, Zerhouni P, Casas R. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008, 359 (18): 1909–20. PMID 18843118. doi:10.1056/NEJMoa0804328. 已忽略未知参数|month=（建议使用|date=） (帮助)
^ Diamyd announces completion of type 1 diabetes vaccine trial with long term efficacy demonstrated at 30 months. Press Release. Diamyd Medical AB. 2008-01-28 [2010-01-13].
^ Woo TU, Walsh JP, Benes FM. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry. 2004, 61 (7): 649–57. PMID 15237077. doi:10.1001/archpsyc.61.7.649.
^ Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (24): 10164–9. PMC 1888575  . PMID 17553960. doi:10.1073/pnas.0703806104.
^ pmid18066140, F; Schjøtt J. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology. 2007, 85 (9): 933–42. PMID 18066140. doi:10.4045/tidsskr.08.0047. 已忽略未知参数|month=（建议使用|date=） (帮助);

添加话题

[pmid1697648-1] Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Camilli PD. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990, 347 (6289): 151–6. PMID 1697648. doi:10.1038/347151a0.

[pmid1370298-2] Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ. Autoimmunity to two forms of 谷氨酸脱羧酶 in insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89 (1): 283–92. PMC 442846  . PMID 1370298. doi:10.1172/JCI115573.

[pmid18843118-3] Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, Lindh A, Nilsson NO, Aman J, Ortqvist E, Zerhouni P, Casas R. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008, 359 (18): 1909–20. PMID 18843118. doi:10.1056/NEJMoa0804328. 已忽略未知参数|month=（建议使用|date=） (帮助)

[url_Diamyd-4] Diamyd announces completion of type 1 diabetes vaccine trial with long term efficacy demonstrated at 30 months. Press Release. Diamyd Medical AB. 2008-01-28 [2010-01-13].

[pmid15237077-5] Woo TU, Walsh JP, Benes FM. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry. 2004, 61 (7): 649–57. PMID 15237077. doi:10.1001/archpsyc.61.7.649.

[pmid17553960-6] Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (24): 10164–9. PMC 1888575  . PMID 17553960. doi:10.1073/pnas.0703806104.

[pmid18066140-7] 18066140, F; Schjøtt J. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology. 2007, 85 (9): 933–42. PMID 18066140. doi:10.4045/tidsskr.08.0047. 已忽略未知参数|month=（建议使用|date=） (帮助);

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