討論:穀氨酸脫羧酶

本條目依照頁面評級標準評為小作品級。
本條目屬於下列維基專題範疇：

（獲評小作品級、低重要度）

	分子與細胞生物學主題閱論編本條目屬於分子與細胞生物學專題範疇，該專題旨在改善中文維基百科分子與細胞生物學類內容。如果您有意參與，請瀏覽專題主頁、參與討論，並完成相應的開放性任務。
小作品	根據專題品質評級標準，本條目已評為小作品級。
低	根據專題重要度評級標準，本條目已評為低重要度。

未翻譯內容

最新留言：13 年前1則留言1個人參與討論

未翻譯內容如下：--Flame 歡迎泡茶 2011年6月19日 (日) 00:28 (UTC)回覆

糖尿病

Both GAD₆₇ and GAD₆₅ are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes.^[1]^[2] Injections with GAD₆₅ has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes.^[3]^[4]

精神分裂症與雙相型障礙

GAD mRNA表達的大量失調，coupled with downregulation of reelin, is observed in 精神分裂症 and 雙相障礙.^[5] The most pronounced downregulation of GAD67 was found in hippocampal stratum oriens layer in both disorders and in other layers and structures of hippocampus with varying degrees.^[6]

藥物引起的改變

普瑞巴林，一種抗癲癇藥, increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity.[1] Extracts from Centella asiatica (gotu kola) and Valeriana officinalis (valerian) stimulated GAD activity.^[7]

外部連結已修改

最新留言：7 年前1則留言1個人參與討論

各位維基人：

我剛剛修改了穀氨酸脫羧酶中的1個外部連結，請大家仔細檢查我的編輯。如果您有疑問，或者需要讓機械人忽略某個連結甚至整個頁面，請訪問這個簡單的FAQ獲取更多信息。我進行了以下修改：

向 http://www.schizophreniaforum.org/new/detail.asp?id=1358 中加入存檔連結 https://web.archive.org/web/20070815162255/http://www.schizophreniaforum.org/new/detail.asp?id=1358

有關機械人修正錯誤的詳情請參閱FAQ。

祝編安。—InternetArchiveBot (報告軟件缺陷) 2017年7月22日 (六) 05:43 (UTC)回覆

^ Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Camilli PD. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990, 347 (6289): 151–6. PMID 1697648. doi:10.1038/347151a0.
^ Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ. Autoimmunity to two forms of 谷氨酸脱羧酶 in insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89 (1): 283–92. PMC 442846  . PMID 1370298. doi:10.1172/JCI115573.
^ Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, Lindh A, Nilsson NO, Aman J, Ortqvist E, Zerhouni P, Casas R. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008, 359 (18): 1909–20. PMID 18843118. doi:10.1056/NEJMoa0804328. 已忽略未知參數|month=（建議使用|date=） (幫助)
^ Diamyd announces completion of type 1 diabetes vaccine trial with long term efficacy demonstrated at 30 months. Press Release. Diamyd Medical AB. 2008-01-28 [2010-01-13].
^ Woo TU, Walsh JP, Benes FM. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry. 2004, 61 (7): 649–57. PMID 15237077. doi:10.1001/archpsyc.61.7.649.
^ Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (24): 10164–9. PMC 1888575  . PMID 17553960. doi:10.1073/pnas.0703806104.
^ pmid18066140, F; Schjøtt J. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology. 2007, 85 (9): 933–42. PMID 18066140. doi:10.4045/tidsskr.08.0047. 已忽略未知參數|month=（建議使用|date=） (幫助);

新增話題

[pmid1697648-1] Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Camilli PD. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990, 347 (6289): 151–6. PMID 1697648. doi:10.1038/347151a0.

[pmid1370298-2] Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ. Autoimmunity to two forms of 谷氨酸脱羧酶 in insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89 (1): 283–92. PMC 442846  . PMID 1370298. doi:10.1172/JCI115573.

[pmid18843118-3] Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, Lindh A, Nilsson NO, Aman J, Ortqvist E, Zerhouni P, Casas R. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008, 359 (18): 1909–20. PMID 18843118. doi:10.1056/NEJMoa0804328. 已忽略未知參數|month=（建議使用|date=） (幫助)

[url_Diamyd-4] Diamyd announces completion of type 1 diabetes vaccine trial with long term efficacy demonstrated at 30 months. Press Release. Diamyd Medical AB. 2008-01-28 [2010-01-13].

[pmid15237077-5] Woo TU, Walsh JP, Benes FM. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry. 2004, 61 (7): 649–57. PMID 15237077. doi:10.1001/archpsyc.61.7.649.

[pmid17553960-6] Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (24): 10164–9. PMC 1888575  . PMID 17553960. doi:10.1073/pnas.0703806104.

[pmid18066140-7] 18066140, F; Schjøtt J. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology. 2007, 85 (9): 933–42. PMID 18066140. doi:10.4045/tidsskr.08.0047. 已忽略未知參數|month=（建議使用|date=） (幫助);

[1]

[2]

[3]

[4]

[5]

[6]

[7]