沃尔夫定律(英语:Wolff's law)是由十九世纪时德国的解剖学家及外科医生朱利叶斯·沃尔夫英语Julius Wolff提出的理论,认为健康的人类或动物的骨骼会适应所在部位需承受的负载[1]。若特定骨骼的负载增加了,骨骼会慢慢的变强壮,来承受该负载[2]。骨中小梁英语trabecula的内在结构会产生适应性的变化,而骨的外层皮层也会随之变化[3],因此也有可能使骨骼变粗。反之亦然,若骨骼负载减少,骨骼也会变细,因为该骨骼的新陈代谢较不需要,而且没有刺激来产生可以维持骨质量的骨的再建英语bone remodeling[4]。这种骨密度的减少(骨质缺乏英语osteopenia)称为应力遮蔽(stress shielding),可能出现在髋关节手术(或是植入其他假体)后的情形。骨骼因为其他的假体承受了应力,因此让骨骼无法承受到正常的应力。

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参考资料

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  1. ^ Anahad O'Connor. The Claim: After Being Broken, Bones Can Become Even Stronger. New York Times. October 18, 2010 [2010-10-19]. (原始内容存档于2014-12-18). This concept — that bone adapts to pressure, or a lack of it — is known as Wolff’s law. ... there is no evidence that a bone that breaks will heal to be stronger than it was before. 
  2. ^ Frost, HM. Wolff's Law and bone's structural adaptations to mechanical usage: an overview for clinicians. The Angle Orthodontist. 1994, 64 (3): 175–188. PMID 8060014. doi:10.1043/0003-3219(1994)064<0175:WLABSA>2.0.CO;2. 
  3. ^ Stedman's Medical Dictionary
  4. ^ Wolff J. "The Law of Bone Remodeling". Berlin Heidelberg New York: Springer, 1986 (translation of the German 1892 edition)
  5. ^ Frost, HM. Bone's mechanostat: a 2003 update. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology. 2003, 275 (2): 1081–1101. PMID 14613308. doi:10.1002/ar.a.10119 . 
  • Das Gesetz der Transformation der Knochen - 1892. Reprint: Pro Business, Berlin 2010, ISBN 978-3-86805-648-8.
  • The Classic: On the Inner Architecture of Bones and its Importance for Bone Growth, Clin Orthop Rel Res. 2010 Apr;468(4):1056-1065

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