NSC-34

NSC-34细胞（Neuroblastoma x Spinal Cord - 34）是一种杂交细胞系，由胚胎小鼠脊髓细胞与神经母细胞瘤细胞N18TG2融合而成^[1]，能表现出许多运动神经元的特性^[2]^[3]，可作为研究肌萎缩性脊髓侧索硬化症（ALS）的体外（in vitro）模型^[4]^[5]。

参考资料

^ Cashman, Neil R.; Durham, Heather D.; Blusztajn, Jan Krzysztof; Oda, Kenichiro; Tabira, Takeshi; Shaw, Ivan T.; Dahrouge, Simone; Antel, Jack P. Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Developmental Dynamics. 1992-07, 194 (3): 209–221. doi:10.1002/aja.1001940306.
^ Matusica, D; Fenech, MP; Rogers, ML; Rush, RA. Characterization and use of the NSC-34 cell line for study of neurotrophin receptor trafficking.. Journal of neuroscience research. 2008-02-15, 86 (3): 553–65. PMID 17896795. doi:10.1002/jnr.21507.
^ Madji Hounoum, B; Vourc'h, P; Felix, R; Corcia, P; Patin, F; Guéguinou, M; Potier-Cartereau, M; Vandier, C; Raoul, C; Andres, CR; Mavel, S; Blasco, H. NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity.. Frontiers in cellular neuroscience. 2016, 10: 118. PMID 27242431. doi:10.3389/fncel.2016.00118.
^ Cascella, Roberta; Bigi, Alessandra; Riffert, Dylan Giorgino; Gagliani, Maria Cristina; Ermini, Emilio; Moretti, Matteo; Cortese, Katia; Cecchi, Cristina; Chiti, Fabrizio. A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43. Science Advances. 2022-07-29, 8 (30). doi:10.1126/sciadv.abm6376.
^ Ding, Qiao; Chaplin, Justin; Morris, Matthew J.; Hilliard, Massimo A.; Wolvetang, Ernst; Ng, Dominic C. H.; Noakes, Peter G. TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells. Frontiers in Cell and Developmental Biology. 2021-06-08, 9. doi:10.3389/fcell.2021.611601.

外部链接

Cellosaurus entry for NSC-34

这是一篇分子与细胞生物学（分子细胞生物学）小作品。您可以通过编辑或修订扩充其内容。

[1] Cashman, Neil R.; Durham, Heather D.; Blusztajn, Jan Krzysztof; Oda, Kenichiro; Tabira, Takeshi; Shaw, Ivan T.; Dahrouge, Simone; Antel, Jack P. Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Developmental Dynamics. 1992-07, 194 (3): 209–221. doi:10.1002/aja.1001940306.

[2] Matusica, D; Fenech, MP; Rogers, ML; Rush, RA. Characterization and use of the NSC-34 cell line for study of neurotrophin receptor trafficking.. Journal of neuroscience research. 2008-02-15, 86 (3): 553–65. PMID 17896795. doi:10.1002/jnr.21507.

[3] Madji Hounoum, B; Vourc'h, P; Felix, R; Corcia, P; Patin, F; Guéguinou, M; Potier-Cartereau, M; Vandier, C; Raoul, C; Andres, CR; Mavel, S; Blasco, H. NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity.. Frontiers in cellular neuroscience. 2016, 10: 118. PMID 27242431. doi:10.3389/fncel.2016.00118.

[4] Cascella, Roberta; Bigi, Alessandra; Riffert, Dylan Giorgino; Gagliani, Maria Cristina; Ermini, Emilio; Moretti, Matteo; Cortese, Katia; Cecchi, Cristina; Chiti, Fabrizio. A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43. Science Advances. 2022-07-29, 8 (30). doi:10.1126/sciadv.abm6376.

[5] Ding, Qiao; Chaplin, Justin; Morris, Matthew J.; Hilliard, Massimo A.; Wolvetang, Ernst; Ng, Dominic C. H.; Noakes, Peter G. TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells. Frontiers in Cell and Developmental Biology. 2021-06-08, 9. doi:10.3389/fcell.2021.611601.

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