4-氯亚苄基丙二腈
化合物
4-氯亚苄基丙二腈是一种有机化合物，化学式为C11H5ClN2，可由丙二腈和4-氯苯甲醛的Knoevenagel反应制得。[3]它和叔丁基碘、三乙基硼在痕量氧的存在下反应，可以得到2-[1-(4-氯苯基)-2,2-二甲基丙基]丙二腈；[4]它和N-氯代丁二酰亚胺在乙酸钠催化下于乙腈中反应，可以得到N-[2-氯-1-(4-氯苯基)-2,2-二氰基乙基]丁二酰亚胺；[5]硼氢化钠可以将其还原为4-氯苄基丙二腈。[6]
| 4-氯亚苄基丙二腈 | |
|---|---|
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| 识别 | |
| CAS号 | 1867-38-5 
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| 性质 | |
| 化学式 | C11H5ClN2 |
| 摩尔质量 | 200.62 g·mol−1 |
| 外观 | 无色晶体 |
| 熔点 | 162—164 °C（435—437 K）[1] |
| 危险性 | |
| GHS提示词 | 危险 |
| H-术语 | H317, H319[2] |
| P-术语 | P280, P305+351+338[2] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参考文献
编辑- ^ Younes Moussaoui, Ridha Ben Salem. Catalyzed Knoevenagel reactions on inorganic solid supports: Application to the synthesis of coumarine compounds. Comptes Rendus Chimie. 2007-12, 10 (12): 1162–1169 [2021-05-31]. doi:10.1016/j.crci.2007.08.007. （原始内容存档于2018-06-17） （英语）.
- ^ 2.0 2.1 4-氯苄亚基丙二腈化学品安全技术说明书. chemBlink. [2021-05-31]. （原始内容存档于2021-06-03）.
- ^ Samahe Sadjadi, Maryam Akbari, Fatemeh Ghoreyshi Kahangi, Majid M. Heravi. Acidic polymer containing sulfunic acid and carboxylic acid groups heterogenized with natural clay: A novel metal free and heterogeneous catalyst for acid-catalyzed reactions. Polyhedron. 2020-03, 179: 114375 [2021-05-31]. doi:10.1016/j.poly.2020.114375 （英语）.
- ^ Jing-Yuan Liu, Yoeng-Jiunn Jang, Wen-Wei Lin, Ju-Tsung Liu, Ching-Fa Yao. Triethylaluminum- or Triethylborane-Induced Free Radical Reaction of Alkyl Iodides and α,β-Unsaturated Compounds. The Journal of Organic Chemistry. 2003-05-01, 68 (10): 4030–4038 [2021-05-31]. ISSN 0022-3263. doi:10.1021/jo020681b （英语）.
- ^ Wenli Li, Zhanguo Chen, Jimei Zhou, Junli Hu, Wei Xia. Sodium Acetate-catalyzed Regiospecific and High Stereoselective Aminobromination of β,β-Dicyanostyrene Derivatives with NBS as Nitrogen/Bromine Source. Chinese Journal of Chemistry. 2012-04, 30 (4): 830–836 [2021-05-31]. doi:10.1002/cjoc.201100346 （英语）.
- ^ Mauger, J.; Robert A. Selective reduction by sodium borohydride of an ester or nitrile group in epoxides gem-disubstituted with two electron attracting groups. Tetrahedron, 1988. 44 (9): 2493-2502. ISSN: 0040-4020.