4-(2-碘乙基)甲苯

4-(2-碘乙基)甲苯
英文名	1-(2-Iodoethyl)-4-methylbenzene
识别
CAS号	120391-67-5
性质
化学式	C9H11I
摩尔质量	246.09 g·mol−1
密度	1.563±0.06 g·cm−3（20 °C）
溶解性（水）	0.0025 g（25 °C）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

4-(2-碘乙基)甲苯是一种有机化合物，化学式为C₉H₁₁I。它可由4-甲基苯乙醇在三苯基膦和咪唑的存在下和碘反应得到^[2]，或由三碘甲烷在DMF中与其直接碘化制得。^[3]

用途

4-(2-碘乙基)甲苯可用于制备含4-甲苯乙基的化合物，例如，它和6-溴-(2H,4H)-1,2,4-三嗪-3,5-二酮在BSA存在下反应，生成6-溴-2-[2-(4-甲苯基)乙基]-(2H,4H)-1,2,4-三嗪-3,5-二酮^[4]；它和三苯基膦反应，可以得到[2-(4-甲苯基)乙基]三苯基碘化𬭸。^[5]

参考文献

^ ^1.0 ^1.1 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-07-26].
^ Tomoyuki Sekino, Shunta Sato, Kazuki Kuwabara, Koji Takizawa, Tatsuhiko Yoshino, Masahiro Kojima, Shigeki Matsunaga. Allyl 4-Chlorophenyl Sulfone as a Versatile 1,1-Synthon for Sequential α-Alkylation/Cobalt-Catalyzed Allylic Substitution. Synthesis. 2020-07, 52 (13): 1934–1946 [2021-07-26]. ISSN 0039-7881. doi:10.1055/s-0040-1707524 （英语）.
^ Yubao Zhao, Markus Antonietti. Visible-Light-Driven Conversion of Alcohols into Iodide Derivatives with Iodoform. ChemPhotoChem. 2018-08, 2 (8): 720–724 [2021-07-26]. doi:10.1002/cptc.201800084 （英语）.
^ Niyada Hin, Bridget Duvall, Dana Ferraris, Jesse Alt, Ajit G. Thomas, Rana Rais, Camilo Rojas, Ying Wu, Krystyna M. Wozniak, Barbara S. Slusher, Takashi Tsukamoto. 6-Hydroxy-1,2,4-triazine-3,5(2 H ,4 H )-dione Derivatives as Novel d -Amino Acid Oxidase Inhibitors. Journal of Medicinal Chemistry. 2015-09-24, 58 (18): 7258–7272 [2021-07-26]. ISSN 0022-2623. PMC 5003509  . PMID 26309148. doi:10.1021/acs.jmedchem.5b00482. （原始内容存档于2021-07-26）（英语）.
^ Baumgartner, Corinne; Flachsmann, Felix; Kraft, Philip. Preparation of substituted alkene derivatives capable of releasing fragrant compounds. 2012 WO 2012085287 A1.

[ACD-1] 1.0 ^1.1 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-07-26].

[2] Tomoyuki Sekino, Shunta Sato, Kazuki Kuwabara, Koji Takizawa, Tatsuhiko Yoshino, Masahiro Kojima, Shigeki Matsunaga. Allyl 4-Chlorophenyl Sulfone as a Versatile 1,1-Synthon for Sequential α-Alkylation/Cobalt-Catalyzed Allylic Substitution. Synthesis. 2020-07, 52 (13): 1934–1946 [2021-07-26]. ISSN 0039-7881. doi:10.1055/s-0040-1707524 （英语）.

[3] Yubao Zhao, Markus Antonietti. Visible-Light-Driven Conversion of Alcohols into Iodide Derivatives with Iodoform. ChemPhotoChem. 2018-08, 2 (8): 720–724 [2021-07-26]. doi:10.1002/cptc.201800084 （英语）.

[4] Niyada Hin, Bridget Duvall, Dana Ferraris, Jesse Alt, Ajit G. Thomas, Rana Rais, Camilo Rojas, Ying Wu, Krystyna M. Wozniak, Barbara S. Slusher, Takashi Tsukamoto. 6-Hydroxy-1,2,4-triazine-3,5(2 H ,4 H )-dione Derivatives as Novel d -Amino Acid Oxidase Inhibitors. Journal of Medicinal Chemistry. 2015-09-24, 58 (18): 7258–7272 [2021-07-26]. ISSN 0022-2623. PMC 5003509  . PMID 26309148. doi:10.1021/acs.jmedchem.5b00482. （原始内容存档于2021-07-26）（英语）.

[5] Baumgartner, Corinne; Flachsmann, Felix; Kraft, Philip. Preparation of substituted alkene derivatives capable of releasing fragrant compounds. 2012 WO 2012085287 A1.

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