EBC-1人类鳞状细胞癌细胞系[1]。EBC-1细胞具有Met基因英语C-Met (一种肝细胞生长因子英语Hepatocyte growth factor受体) 显著扩增及过度表达Met受体的特征,这些受体持续地被磷酸化,并且发现β-连环蛋白p120英语CTNND1/δ-连环蛋白英语Delta catenin磷酸化酪氨酸的上升趋势[2]小发夹RNA介导的Met基因敲落在EBC-1细胞中,显著诱导着生长的抑制细胞凋亡,而其对没有Met基因扩增的细胞系几乎没有任何影响。这些实验结果表明Met基因的扩增,可以鉴定出对靶向Met基因的新分子疗法 (molecular therapies) ,存在反应的非小细胞肺癌英语Non-small-cell lung carcinoma子集[2]

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  1. ^ KIMURA, MICHITAKA; NAITO, HIROSHI; TOJO, TAKASHI; ITAYA-HIRONAKA, ASAKO; DOHI, YOSHIKO; YOSHIMURA, MAMIKO; NAKAGAWARA, KAN-ICHI; TAKASAWA, SHIN; TANIGUCHI, SHIGEKI. REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms. Oncology Reports. 2013-12, 30 (6): 2625–2631. doi:10.3892/or.2013.2739. 
  2. ^ 2.0 2.1 Lutterbach, B; Zeng, Q; Davis, LJ; Hatch, H; Hang, G; Kohl, NE; Gibbs, JB; Pan, BS. Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival.. Cancer research. 2007-03-01, 67 (5): 2081–8 [2019-12-24]. PMID 17332337. doi:10.1158/0008-5472.CAN-06-3495. (原始内容存档于2019-12-24). 

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