龍腦香醇酮

化合物

龍腦香醇酮(英語:Dipterocarpol),別名羥基達瑪烯酮II(英語:Hydroxydammarenone II),是一種有機化合物,化學式C30H50O2,可見於Dysoxylum malabaricum英語Dysoxylum malabaricum[1]鴉膽子[2]等物種。它是麝香心痛寧及複方丹參滴丸的生物活性組分之一。[3][4]

龍腦香醇酮
英文名 Dipterocarpol
別名 20-羥基達瑪-24-烯-3-酮
識別
CAS號 471-69-2  checkY
PubChem 441676
ChemSpider 390290
SMILES
 
  • CC(=CCCC(C)(C1CCC2(C1CCC3C2(CCC4C3(CCC(=O)C4(C)C)C)C)C)O)C
InChI
 
  • InChI=1S/C30H50O2/c1-20(2)10-9-16-30(8,32)22-13-18-28(6)21(22)11-12-24-27(5)17-15-25(31)26(3,4)23(27)14-19-29(24,28)7/h10,21-24,32H,9,11-19H2,1-8H3/t21-,22+,23+,24-,27+,28-,29-,30+/m1/s1
InChIKey NJICGAVMYWKCMW-GWJXCKMPSA-N
ChEBI 4652
性質
化學式 C30H50O2
摩爾質量 442.72 g·mol−1
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

它可以羥基藿烷酮為原料經多步反應製得。[5]

參考資料

編輯
  1. ^ Hisham A; Bai A; JayaKumar G; Nair MS; Fujimoto Y. Triterpenoids from Dysoxylum malabaricum.. Phytochemistry. 2001-02, 56 (4). doi:10.1016/S0031-9422(00)00413-1. 
  2. ^ Tzong-Huei Lee; Jong-Liang Chiou; Ching-Kuo Lee; Yueh-Hsiung Kuo. Separation and Determination of Chemical Constituents in the Roots ofRhus JavanicaL. Var.Roxburghiana. Journal of the Chinese Chemical Society. 2005-08, 52 (4). doi:10.1002/JCCS.200500117. 
  3. ^ Xiaohong Wang; Jiawei Zhou; Tianlin Jiang; Jun Xu. Deciphering the therapeutic potential of SheXiangXinTongNing: Interplay between gut microbiota and brain metabolomics in a CUMS mice model, with a focus on tryptophan metabolism. Phytomedicine, 2024. 129. 155584. doi:10.1016/j.phymed.2024.155584.
  4. ^ Tian, Xiaocui; Yin, Shiqi; Liu, Zhiguang; Cao, Jinglin; Liu, Xinyu; Qiu, Qi. Elucidation of the Molecular Mechanism of Compound Danshen Dripping Pills against Angina Pectoris based on Network Pharmacology and Molecular Docking. Current Pharmaceutical Design (2024), 30(16), 1247-1264. doi:10.2174/0113816128287109240321074628.
  5. ^ Ryoji Kasai; Keiko Shinzo; Osamu Tanaka. Syntheses of Betulafolienetriol and the Ginseng Sapogenin, 20 (S)-Protopanaxadiol. Chemical and Pharmaceutical Bulletin, 1976. 24 (3). doi:10.1248/cpb.24.400.