煙麴黴醇
化合物
煙麴黴醇(英語:Fumagillol)是一種有機化合物,化學式C16H26O4,屬於一種環氧化合物,存在於Penicillium jensenii(Penicillium jensenii)[1]、煙麴黴(Aspergillus fumigatus)[2]等真菌中,與其酯煙麴黴素是全合成的重要目標[3][4][5]。
煙麴黴醇 | |
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英文名 | fumagillol |
識別 | |
CAS號 | |
PubChem | 222778 |
ChemSpider | 193433 |
SMILES |
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InChI |
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InChIKey | CEVCTNCUIVEQOY-JQOWZUPLSA-N |
ChEBI | 324935 |
性質 | |
化學式 | C16H26O4 |
摩爾質量 | 282.38 g·mol−1 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
參考文獻
編輯- ^ Hatanaka, Hiroshi; Kino, Toru; Hashimoto, Michizane; Tsurumi, Yasuhisa; Kuroda, Akio; Tanaka, Hirokazu; Goto, Tosmo; Okuhara, Masakuni. FR65814, a novel immunosuppressant isolated from a Penicillium strain. Taxonomy, fermentation, isolation, physico-chemical and biological characteristics and structure assignment.. The Journal of Antibiotics. 1988, 41 (8): 999–1008. doi:10.7164/ANTIBIOTICS.41.999.
- ^ Lin, HC; Chooi, YH; Dhingra, S; Xu, W; Calvo, AM; Tang, Y. The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene.. Journal of the American Chemical Society. 2013-03-27, 135 (12): 4616–9. PMID 23488861. doi:10.1021/ja312503y.
- ^ Corey EJ, Snider BB. A total synthesis of (+-)-fumagillin. Journal of the American Chemical Society. April 1972, 94 (7): 2549–2550. PMID 5016935. doi:10.1021/ja00762a080.
- ^ Kim D, Ahn SK, Bae H, Choi WJ, Kim HS. An asymmetric total synthesis of (−)-fumagillol. Tetrahedron Letters. 1997, 38 (25): 4437–4440. doi:10.1016/S0040-4039(97)00925-8.
- ^ Vosburg DA, Weiler S, Sorensen EJ. A Concise Synthesis of Fumagillol. Angewandte Chemie. April 1999, 38 (7): 971–974. PMID 29711854. doi:10.1002/(SICI)1521-3773(19990401)38:7<971::AID-ANIE971>3.0.CO;2-W.