ERG11甾醇-14-去甲基酶(Sterol 14-demethylase)是一種真菌細胞色素P450,最初發現於釀酒酵母Saccharomyces cerevisiae基因組,屬於CYP51家族,代號CYP51F1[1]。ERG11催化羊毛甾醇轉化為酵母甾醇的第一步,羊毛甾醇的14α-去甲基化生成4,4-二甲基-5α-膽甾-8(9),14,24-三烯-3β-醇,酵母甾醇會進一步生成麥角固醇[2]

Sterol 14-demethylase
標識
生物 Saccharomyces cerevisiae
符號 ERG11
可選符號 CYP51F1
Entrez 856398
RefSeq (mRNA) NM_001179137
RefSeq (蛋白質) NP_011871
UniProt P10614
其他數據
EC number 1.14.14.154
染色體 VIII: 0.12 - 0.12 Mb

參考文獻

編輯
  1. ^ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. Global analysis of protein expression in yeast. Nature. October 2003, 425 (6959): 737–41. Bibcode:2003Natur.425..737G. PMID 14562106. doi:10.1038/nature02046. 
  2. ^ Mo C, Bard M. Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex. Journal of Lipid Research. September 2005, 46 (9): 1991–8. PMID 15995173. doi:10.1194/jlr.M500153-JLR200.