咪唑并[4,5-f][1,10]菲啰啉

咪唑並[4,5-f][1,10]菲囉啉
英文名	1H-Imidazo[4,5-f][1,10]phenanthroline
別名	1H-咪唑並[4,5-f][1,10]菲囉啉; IPM713
識別
CAS號	171565-43-8
性質
化學式	C13H8N4
摩爾質量	220.23 g·mol⁻¹
外觀	白色固體
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

咪唑並[4,5-f][1,10]菲囉啉是一種有機化合物，化學式為C₁₃H₈N₄。它可由1,10-菲囉啉-5,6-二酮、甲醛、乙酸銨和冰乙酸在惰性氣氛中回流反應得到，它經水稀釋後，用氨水調節pH至中性後析出。^[1]它和2-碘丙烷在碳酸銫存在下於乙腈中反應，可以得到1-異丙基咪唑並[4,5-f][1,10]菲囉啉。^[2]很多金屬可以和其菲囉啉氮配位，形成配位化合物。^[3]^[4]

參考文獻

^ Shujian Hu, Wantong Ma, Junyi Wang, Zhongkun Zhou, Yunhao Ma, Rentao Zhang, Kangjia Du, Hao Zhang, Mengze Sun, Xinrong Jiang, Hongyuan Tu, Xiaoliang Tang, Xiaojun Yao, Peng Chen. Synthesis and biological activity of 1H-imidazo[4,5-f][1,10]phenanthroline as a potential antitumor agent with PI3K/AKT/mTOR signaling. European Journal of Pharmacology. 2022-01, 915: 174514 [2022-05-16]. doi:10.1016/j.ejphar.2021.174514 （英語）.
^ James W. Pearson, Riley T. Endean, Loorthuraja Rasu, Steven H. Bergens. Investigation into the properties of a ruthenium(polypyridyl)-NHC compound. Canadian Journal of Chemistry. 2021-02, 99 (2): 230–235 [2022-05-16]. ISSN 0008-4042. doi:10.1139/cjc-2020-0397. （原始內容存檔於2022-05-16）（英語）.
^ Guang-Bo Che, Shan-Shan Wang, Xiao-Lin Zha, Xiu-Ying Li, Chun-Bo Liu, Xing-Jing Zhang, Zhan-Lin Xu, Qing-Wei Wang. Syntheses, structures, and photoluminescence of a series of d10 coordination complexes from N,N′-bidentate imidazo[4,5-f][1,10]phenanthroline and benzene-1,3,5-tricarboxylic acid. Inorganica Chimica Acta. 2013-01, 394: 481–487 [2022-05-16]. doi:10.1016/j.ica.2012.09.007. （原始內容存檔於2020-02-21）（英語）.
^ Lütfiye Gök, Salih Günnaz, Zarife Sibel Şahin, Levent Pelit, Hayati Türkmen. The imidazo{[4,5-f][1,10]-phenanthrolin}l-2-ylidene and its palladium complexes: Synthesis, characterization, and application in C-C cross-coupling reactions. Journal of Organometallic Chemistry. 2017-01, 827: 96–104 [2022-05-16]. doi:10.1016/j.jorganchem.2016.11.013. （原始內容存檔於2020-03-02）（英語）.

參見

mTOR抑制劑（英語：mTOR inhibitors）

[1] Shujian Hu, Wantong Ma, Junyi Wang, Zhongkun Zhou, Yunhao Ma, Rentao Zhang, Kangjia Du, Hao Zhang, Mengze Sun, Xinrong Jiang, Hongyuan Tu, Xiaoliang Tang, Xiaojun Yao, Peng Chen. Synthesis and biological activity of 1H-imidazo[4,5-f][1,10]phenanthroline as a potential antitumor agent with PI3K/AKT/mTOR signaling. European Journal of Pharmacology. 2022-01, 915: 174514 [2022-05-16]. doi:10.1016/j.ejphar.2021.174514 （英語）.

[2] James W. Pearson, Riley T. Endean, Loorthuraja Rasu, Steven H. Bergens. Investigation into the properties of a ruthenium(polypyridyl)-NHC compound. Canadian Journal of Chemistry. 2021-02, 99 (2): 230–235 [2022-05-16]. ISSN 0008-4042. doi:10.1139/cjc-2020-0397. （原始內容存檔於2022-05-16）（英語）.

[3] Guang-Bo Che, Shan-Shan Wang, Xiao-Lin Zha, Xiu-Ying Li, Chun-Bo Liu, Xing-Jing Zhang, Zhan-Lin Xu, Qing-Wei Wang. Syntheses, structures, and photoluminescence of a series of d10 coordination complexes from N,N′-bidentate imidazo[4,5-f][1,10]phenanthroline and benzene-1,3,5-tricarboxylic acid. Inorganica Chimica Acta. 2013-01, 394: 481–487 [2022-05-16]. doi:10.1016/j.ica.2012.09.007. （原始內容存檔於2020-02-21）（英語）.

[4] Lütfiye Gök, Salih Günnaz, Zarife Sibel Şahin, Levent Pelit, Hayati Türkmen. The imidazo{[4,5-f][1,10]-phenanthrolin}l-2-ylidene and its palladium complexes: Synthesis, characterization, and application in C-C cross-coupling reactions. Journal of Organometallic Chemistry. 2017-01, 827: 96–104 [2022-05-16]. doi:10.1016/j.jorganchem.2016.11.013. （原始內容存檔於2020-03-02）（英語）.

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