费莉莎·沃尔夫-西蒙

Felisa Lauren Wolfe-Simon
Felisa Lauren Wolfe-Simon
	2011年《时代》百大人物庆典上的沃尔夫－西蒙
出生	Felisa Lauren Wolfe
母校	罗格斯大学(Ph.D.); 欧柏林学院 (B.A.); 欧柏林音乐学院 (B.M.)
知名于	GFAJ-1细菌
	科学生涯
研究领域	生物化学; 微生物学; 天体生物学; 地球化学; 地质微生物学; 海洋学
机构	劳伦斯伯克利国家实验室; NASA天体生物学研究所; 美国地质调查局; 罗格斯大学
博士导师	保罗·G·法尔科夫斯基

费莉莎·沃尔夫-西蒙（英语：Felisa Wolfe-Simon）是一位美国微生物地球生物学和生物地球化学家。

生平

2010年，沃尔夫－西蒙领导的团队发现了一种嗜极细菌 GFAJ-1，可在高含砷低含磷的条件下生长^[1]^[2]，最初沃尔夫－西蒙认为这种细菌可能使用砷酸替代磷酸作为DNA的骨架^[3]，但后来罗茜·雷德菲尔德等人的实验证明这种细菌只是抵抗砷而非利用砷^[4]^[5]。

参考文献

^ Wolfe-Simon, F.; Blum, J. S.; Kulp, T. R.; Gordon, G. W.; Hoeft, S. E.; Pett-Ridge, J.; Stolz, J. F.; Webb, S. M.; Weber, P. K.; Davies, P. C. W.; Anbar, A. D.; Oremland, R. S. A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus. Science. 2010, 332 (6034): 1163–1166. Bibcode:2011Sci...332.1163W. PMID 21127214. doi:10.1126/science.1197258  .
^ Wolfe-Simon, F.; Blum, J. S.; Kulp, T. R.; Gordon, G. W.; Hoeft, S. E.; Pett-Ridge, J.; Stolz, J. F.; Webb, S. M.; Weber, P. K.; Davies, P. C. W.; Anbar, A. D.; Oremland, R. S. Response to Comments on "A Bacterium That Can Grow Using Arsenic Instead of Phosphorus". Science. 27 May 2011, 332 (6034): 1149. Bibcode:2011Sci...332.1149W. doi:10.1126/science.1202098  .
^ Drahl, C. The Arsenic-Based-Life Aftermath. Researchers challenge a sensational claim, while others revisit arsenic biochemistry, Chem Eng News 90(5), 42-47, January 30, 2012. http://cen.acs.org/articles/90/i5/Arsenic-Based-Life-Aftermath.html （页面存档备份，存于互联网档案馆）; accessed 13 October 2012
^ Erb, T. J.; Kiefer, P.; Hattendorf, B.; Gunther, D.; Vorholt, J. A. GFAJ-1 Is an Arsenate-Resistant, Phosphate-Dependent Organism. Science. 2012, 337 (6093): 467–470. Bibcode:2012Sci...337..467E. PMID 22773139. doi:10.1126/science.1218455.
^ Reaves, M. L.; Sinha, S.; Rabinowitz, J. D.; Kruglyak, L.; Redfield, R. J. Absence of Detectable Arsenate in DNA from Arsenate-Grown GFAJ-1 Cells. Science. 2012, 337 (6093): 470–473. Bibcode:2012Sci...337..470R. PMC 3845625  . PMID 22773140. arXiv:1201.6643  . doi:10.1126/science.1219861.

[Wolfe-Simon_et_al_2010-1] Wolfe-Simon, F.; Blum, J. S.; Kulp, T. R.; Gordon, G. W.; Hoeft, S. E.; Pett-Ridge, J.; Stolz, J. F.; Webb, S. M.; Weber, P. K.; Davies, P. C. W.; Anbar, A. D.; Oremland, R. S. A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus. Science. 2010, 332 (6034): 1163–1166. Bibcode:2011Sci...332.1163W. PMID 21127214. doi:10.1126/science.1197258  .

[2] Wolfe-Simon, F.; Blum, J. S.; Kulp, T. R.; Gordon, G. W.; Hoeft, S. E.; Pett-Ridge, J.; Stolz, J. F.; Webb, S. M.; Weber, P. K.; Davies, P. C. W.; Anbar, A. D.; Oremland, R. S. Response to Comments on "A Bacterium That Can Grow Using Arsenic Instead of Phosphorus". Science. 27 May 2011, 332 (6034): 1149. Bibcode:2011Sci...332.1149W. doi:10.1126/science.1202098  .

[3] Drahl, C. The Arsenic-Based-Life Aftermath. Researchers challenge a sensational claim, while others revisit arsenic biochemistry, Chem Eng News 90(5), 42-47, January 30, 2012. http://cen.acs.org/articles/90/i5/Arsenic-Based-Life-Aftermath.html （页面存档备份，存于互联网档案馆）; accessed 13 October 2012

[4] Erb, T. J.; Kiefer, P.; Hattendorf, B.; Gunther, D.; Vorholt, J. A. GFAJ-1 Is an Arsenate-Resistant, Phosphate-Dependent Organism. Science. 2012, 337 (6093): 467–470. Bibcode:2012Sci...337..467E. PMID 22773139. doi:10.1126/science.1218455.

[5] Reaves, M. L.; Sinha, S.; Rabinowitz, J. D.; Kruglyak, L.; Redfield, R. J. Absence of Detectable Arsenate in DNA from Arsenate-Grown GFAJ-1 Cells. Science. 2012, 337 (6093): 470–473. Bibcode:2012Sci...337..470R. PMC 3845625  . PMID 22773140. arXiv:1201.6643  . doi:10.1126/science.1219861.

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