BV2

BV2细胞是最常用的鼠源小胶质细胞细胞系^[1]，来自于一周龄的雌性C57BL/6 实验小鼠，通过感染带有v-raf/v-myc癌基因的J2逆转录病毒实现永生化^[2]，用于一些神经退行性疾病研究^[3]。

参考资料

^ Henn, A; Lund, S; Hedtjärn, M; Schrattenholz, A; Pörzgen, P; Leist, M. The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation.. ALTEX. 2009, 26 (2): 83–94. PMID 19565166. doi:10.14573/altex.2009.2.83.
^ Blasi, E; Barluzzi, R; Bocchini, V; Mazzolla, R; Bistoni, F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus.. Journal of neuroimmunology. 1990-05, 27 (2-3): 229–37. PMID 2110186. doi:10.1016/0165-5728(90)90073-v.
^ Crain, JM; Watters, JJ. Estrogen and P2 Purinergic Receptor Systems in Microglia: Therapeutic Targets for Neuroprotection.. The open drug discovery journal. 2010-01-01, 2: 148–167. PMID 21961028. doi:10.2174/1877381801002010148.

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