加格列净
加格列净(分子式:C25H29ClO6,化学名:(1S)-1,5-脱水-1-C-[3-[4-[(1α,3α,5α)-双环[3.1.0]己-3-基氧基]苄基-4-氯苯基]-D-葡萄糖醇)是一种由四环医药研发的实验性SGLT2抑制剂,[1]用于治疗糖尿病。[2]
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CAS号 | 1800115-22-3 ![]() |
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化学信息 | |
化学式 | C25H29ClO6 |
摩尔质量 | 460.95 g·mol−1 |
3D模型(JSmol) | |
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它可以2-氯-5-溴苯甲酸和3-环戊烯-1-醇为原料,经多步反应制得。[3]
参考文献
编辑- ^ Song, Ling; Yao, Xueting; Liu, Yang; Zhong, Wen; Jiang, Ji; Liu, Hongzhong; Zhou, Huimin; Shi, Chongtie; Zong, Kaiqi; Wang, Chong; Ma, Chuanxiang; Liu, Dongyang; Hu, Pei. Translational prediction of first-in-human pharmacokinetics and pharmacodynamics of janagliflozin, a selective SGLT2 inhibitor, using allometric scaling, dedrick and PK/PD modeling methods. European Journal of Pharmaceutical Sciences. April 2020, 147: 105281. doi:10.1016/j.ejps.2020.105281.
- ^ 惠升生物加格列净片. 四环医药. [2023-12-14]. (原始内容存档于2023-12-14).
- ^ Wu, Frank. Optically pure benzyl-4-chlorophenyl-C-glucoside derivatives as SGLT inhibitors (diabetes mellitus). 2015. EP2891654.