水迷宫
水迷宫(water maze),是一种用来测验动物记忆的实验设备,其中的路径充满了水,使动物具有逃脱的动机 。[1]
存在许多不同的水迷宫,如T-和Y-迷宫、辛辛那提水迷宫和放射臂迷宫。[2][3][4]水迷宫被用来测试辨别学习和空间学习能力。莫里斯水航行任务通常也称作一个“水迷宫任务”,但是严格地说,它并不是一个迷宫。这些迷宫辅助研究的发展,例如海马突触可塑性、NMDA受体功能和研究神经退化性疾病,如阿尔茨海默氏症。
参考文献
编辑- ^ Schenk, Françoise. 5: The Morris Water Maze (is not a maze). Foreman, Nigel; Gillett, Raphael (编). Handbook of Spatial Research Paradigms and Methodologies. Volume 2: Clinical and Comparative Studies. East Sussex, United Kingdom: Psychology Press. 1998: 145–188 [2017-11-30]. ISBN 978-0-86377-807-0. (原始内容存档于2017-12-01).
- ^ Inheritance of discrimination learning ability and retention in BA and DBA mice. Behavior Genetics. March 1981, 11 (2): 173–177. PMID 7271683. doi:10.1007/BF01065628.
- ^ Vorhees, Charles V.; Williams, Michael T. Cincinnati water maze: A review of the development, methods, and evidence as a test of egocentric learning and memory. Neurotoxicology and Teratology: 1–19. PMC 5056837 . PMID 27545092. doi:10.1016/j.ntt.2016.08.002.
- ^ Water version of the radial-arm maze: learning in three inbred strains of mice. Brain Research. March 1998, 785 (2): 236–244 [2014-05-23]. PMID 9518631. doi:10.1016/S0006-8993(97)01417-0.