CYP305M2

标识
生物	飞蝗
符号	CYP305M2
UniProt	A0A410UD22
其他数据
EC number	1.14.-.-

细胞色素P305M2（CYP305M2，旧称LM16181）是飞蝗的一种细胞色素P450，于2019年由中国科学院的研究团队发表，其氨基酸序列与其他昆虫的细胞色素P305A（CYP305A）较为接近。CYP305M2可催化蝗虫体内苯乙腈生物合成的一个关键步骤，后者对鸟类等蝗虫的天敌具警戒作用，并可在蝗虫被攻击时进一步转换成具毒性的氰化氢^[1]^[2]。蝗虫有散居型（solitary）与聚居型（gregarious）两种型态，其中只有聚居型的蝗虫会表现CYP305M2基因并合成苯乙腈，CYP305M2广泛分布于其组织中，尤以头部和后肢的浓度较高；散居型的蝗虫则阙如^[1]。

参考文献

^ ^1.0 ^1.1 Wei J, Shao W, Cao M, Ge J, Yang P, Chen L, Wang X, Kang L. Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor. Science Advances. January 2019, 5 (1): eaav5495. PMC 6357733  . PMID 30746481. doi:10.1126/sciadv.aav5495.
^ Cytochrome P450 [Locusta migratoria]. NCBI Protein. National Center for Biotechnology Information, U.S. National Library of Medicine.

[Wei_2019-1] 1.0 ^1.1 Wei J, Shao W, Cao M, Ge J, Yang P, Chen L, Wang X, Kang L. Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor. Science Advances. January 2019, 5 (1): eaav5495. PMC 6357733  . PMID 30746481. doi:10.1126/sciadv.aav5495.

[2] Cytochrome P450 [Locusta migratoria]. NCBI Protein. National Center for Biotechnology Information, U.S. National Library of Medicine.

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