A2780

A2780是分離於未接受任何治療的人類女性卵巢癌患者的上皮性卵巢癌細胞系^[1]，因對基質膜的粘附能力弱而具有強烈的遷移侵襲能力，故而惡性程度高。卵巢癌特異性結合肽 (OSTP) 對A2780細胞具有特異結合作用^[2]。有研究指出新藤黃酸能誘導A2780細胞發生粒線體的凋亡，並且抑制細胞的生長及增殖^[3]。同時又有研究指出敲除CKS2（英語：CKS2）能夠抑制A2780細胞中CDC42-V1 mRNA的表達，同時增強CDC42-V2 mRNA的表達，從而抑制絲足（英語：Filopodia）的形成及細胞的遷移能力^[4]。

參考資料

^ Janczar, S; Graham, JS; Paige, AJW; Gabra, H. Targeting locoregional peritoneal dissemination in ovarian cancer. Expert Review of Obstetrics & Gynecology. 2014-01-10, 4 (2): 133–147. doi:10.1586/17474108.4.2.133.
^ Yang, C; He, X; Liu, X; Tang, Z; Liang, X. OSTP as a novel peptide specifically targeting human ovarian cancer.. Oncology reports. 2015-08, 34 (2): 972–8 [2019-12-07]. PMID 26081347. doi:10.3892/or.2015.4066.
^ CHENG Hui; LI Qing-lin; HOU Mei; SU Jing-jing. Effect of Gambogenic Acid on the Apoptosis of Ovarian Cancer Cell Line A2780. Journal of Anhui University of Chinese Medicine. 2019, (1): 58–62 [2019-12-07]. doi:10.3969/j.isn.2095-7246.2019.01.016. （原始內容存檔於2019-12-07）.
^ Qian-ling, SUN; Meng-meng, DONG; YI, Yi; Jin-hui, HU; Mi-ni, ZHANG. Alternate title: CKS2 affects filopodia formation of A2780 cells through regulating CDC42 alternative splicing. Jie Fang Jun Yi Xue Za Zhi. 2016, 41 (8): 618–623. doi:10.11855/j.issn.0577-7402.2016.08.02.

外部連結

Cellosaurus entry for A2780（頁面存檔備份，存於網際網路檔案館）

這是一篇與醫學相關的小作品。您可以透過編輯或修訂擴充其內容。

[1] Janczar, S; Graham, JS; Paige, AJW; Gabra, H. Targeting locoregional peritoneal dissemination in ovarian cancer. Expert Review of Obstetrics & Gynecology. 2014-01-10, 4 (2): 133–147. doi:10.1586/17474108.4.2.133.

[2] Yang, C; He, X; Liu, X; Tang, Z; Liang, X. OSTP as a novel peptide specifically targeting human ovarian cancer.. Oncology reports. 2015-08, 34 (2): 972–8 [2019-12-07]. PMID 26081347. doi:10.3892/or.2015.4066.

[3] CHENG Hui; LI Qing-lin; HOU Mei; SU Jing-jing. Effect of Gambogenic Acid on the Apoptosis of Ovarian Cancer Cell Line A2780. Journal of Anhui University of Chinese Medicine. 2019, (1): 58–62 [2019-12-07]. doi:10.3969/j.isn.2095-7246.2019.01.016. （原始內容存檔於2019-12-07）.

[4] Qian-ling, SUN; Meng-meng, DONG; YI, Yi; Jin-hui, HU; Mi-ni, ZHANG. Alternate title: CKS2 affects filopodia formation of A2780 cells through regulating CDC42 alternative splicing. Jie Fang Jun Yi Xue Za Zhi. 2016, 41 (8): 618–623. doi:10.11855/j.issn.0577-7402.2016.08.02.

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