依美昔单抗

依美昔单抗
单克隆抗体
种类	完整抗体
目標	GD3神经节苷脂
臨床資料
ATC碼	未分配;
识别信息
CAS号	292819-64-8
ChemSpider	none;
UNII	M76FX2JZRM;
化学信息
摩尔质量	145255 g/mol

依美昔单抗（INN：ecromeximab；开发代号：KW2871）是一种嵌合单克隆抗体，正在开发用于治疗恶性黑色素瘤。^[1]^[2]该药物被用来针对转移性黑色素瘤进行I期临床试验，^[3]并在随后与高剂量的干扰素α2b联合进行了II期临床试验。^[4]^[5]

该药物由协和发酵工业株式会社开发。截至2015年12月，开发已停止。^[6]

参考资料

^ Statement On A Nonproprietary Name Adopted By The USAN Council - Ecromeximab （页面存档备份，存于互联网档案馆）, American Medical Association.
^ Clinical trial number NCT00679289 for "Phase II Study of KW2871 Combined With High Dose Interferon-alpha2b in Patients With Metastatic Cutaneous Melanoma" at ClinicalTrials.gov
^ Forero, Andres; Shah, Jatin; Carlisle, Ronda; Triozzi, Pierre L.; LoBuglio, Albert F.; Wang, Wen-Quan; Fujimori, Matt; Conry, Robert M. A phase I study of an anti-GD3 monoclonal antibody, KW-2871, in patients with metastatic melanoma. Cancer Biotherapy & Radiopharmaceuticals. 2006-12, 21 (6) [2024-03-06]. ISSN 1084-9785. PMID 17257071. doi:10.1089/cbr.2006.21.561. （原始内容存档于2024-06-04）.
^ Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma - Full Text View - ClinicalTrials.gov. clinicaltrials.gov. [2024-03-06]. （原始内容存档于2021-04-10）（英语）.
^ Tarhini, Ahmad A.; Moschos, Stergios J.; Lin, Yan; Lin, Hui-Min; Sander, Cindy; Yin, Yan; Venhaus, Ralph; Gajewski, Thomas F.; Kirkwood, John M. Safety and efficacy of the antiganglioside GD3 antibody ecromeximab (KW2871) combined with high-dose interferon-α2b in patients with metastatic melanoma. Melanoma Research. 2017-08, 27 (4) [2024-03-06]. ISSN 1473-5636. PMID 28489678. doi:10.1097/CMR.0000000000000353. （原始内容存档于2024-06-03）.
^ Adis insight: Ecromeximab. [2024-03-06]. （原始内容存档于2017-01-03）.

[1] Statement On A Nonproprietary Name Adopted By The USAN Council - Ecromeximab （页面存档备份，存于互联网档案馆）, American Medical Association.

[2] Clinical trial number NCT00679289 for "Phase II Study of KW2871 Combined With High Dose Interferon-alpha2b in Patients With Metastatic Cutaneous Melanoma" at ClinicalTrials.gov

[3] Forero, Andres; Shah, Jatin; Carlisle, Ronda; Triozzi, Pierre L.; LoBuglio, Albert F.; Wang, Wen-Quan; Fujimori, Matt; Conry, Robert M. A phase I study of an anti-GD3 monoclonal antibody, KW-2871, in patients with metastatic melanoma. Cancer Biotherapy & Radiopharmaceuticals. 2006-12, 21 (6) [2024-03-06]. ISSN 1084-9785. PMID 17257071. doi:10.1089/cbr.2006.21.561. （原始内容存档于2024-06-04）.

[4] Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma - Full Text View - ClinicalTrials.gov. clinicaltrials.gov. [2024-03-06]. （原始内容存档于2021-04-10）（英语）.

[5] Tarhini, Ahmad A.; Moschos, Stergios J.; Lin, Yan; Lin, Hui-Min; Sander, Cindy; Yin, Yan; Venhaus, Ralph; Gajewski, Thomas F.; Kirkwood, John M. Safety and efficacy of the antiganglioside GD3 antibody ecromeximab (KW2871) combined with high-dose interferon-α2b in patients with metastatic melanoma. Melanoma Research. 2017-08, 27 (4) [2024-03-06]. ISSN 1473-5636. PMID 28489678. doi:10.1097/CMR.0000000000000353. （原始内容存档于2024-06-03）.

[6] Adis insight: Ecromeximab. [2024-03-06]. （原始内容存档于2017-01-03）.

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