2-氯硬脂酸
2-氯硬脂酸是一种有机氯化合物，化学式为C18H35ClO2。它可由硬脂酸和氯气在氯磺酸和TCNQ的存在下反应制得，[2]或由硬脂酸和三氯化磷、三氯异氰脲酸反应得到。[1]它在氢氧化钾水溶液中回流，再酸化后可以得到2-羟基硬脂酸。[1]
| 2-氯硬脂酸 | |
|---|---|
| |
| 别名 | 2-氯十八酸 |
| 识别 | |
| CAS号 | 56279-49-3 
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| PubChem | 13059777 |
| SMILES |
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| 性质 | |
| 化学式 | C18H35ClO2 |
| 摩尔质量 | 318.92 g·mol−1 |
| 外观 | 白色固体 |
| 熔点 | 62.2 °C[1] 63.5~64.5 °C[2] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参考文献
编辑- ^ 1.0 1.1 1.2 Valentina Bertolini, Marco Pallavicini, Gaurao Tibhe, Gabriella Roda, Sebastiano Arnoldi, Laura Monguzzi, Marina Zoccola, Giovanna Di Nardo, Gianfranco Gilardi, and Cristiano Bolchi. Synthesis of α-Hydroxy Fatty Acids from Fatty Acids by Intermediate α-Chlorination with TCCA under Solvent-Free Conditions: A Way to Valorization of Waste Fat Biomasses. ACS Omega 2021, 6, 47, 31901–31906. doi:10.1021/acsomega.1c04640.
- ^ 2.0 2.1 Robert J. Crawford. An improved α-chlorination of carboxylic acids. J. Org. Chem. 1983, 48, 8, 1364–1366. doi:10.1021/jo00156a047.
拓展阅读
编辑- Amunugama, Kaushalya; Kolar, Grant R.; Ford, David A. Neutrophil myeloperoxidase derived chlorolipid production during bacteria exposure. Frontiers in Immunology (2021), 12, 701227. doi:10.3389/fimmu.2021.701227.
- Ford, David A.; Honavar, Jaideep; Albert, Carolyn J.; Duerr, Mark A.; Oh, Joo Yeun; Doran, Stephen; Matalon, Sadis; Patel, Rakesh P. Formation of chlorinated lipids post-chlorine gas exposure. Journal of Lipid Research (2016), 57(8), 1529-1540. doi:10.1194/jlr.M069005.