凝血酶

凝血因子II（凝血酶）
凝血因子II（凝血酶）
	人类凝血酶结构，与其抑制剂水蛭素结合在一起
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1a2c, 1a3b, 1a3e, 1a46, 1a4w, 1a5g, 1a61, 1abi, 1abj, 1ad8, 1ae8, 1afe, 1aht, 1ai8, 1aix, 1awf, 1awh, 1ay6, 1b5g, 1b7x, 1ba8, 1bb0, 1bbr, 1bcu, 1bhx, 1bmm, 1bmn, 1bth, 1c1u, 1c1v, 1c1w, 1c4u, 1c4v, 1c4y, 1c5l, 1c5n, 1c5o, 1ca8, 1d3d, 1d3p, 1d3q, 1d3t, 1d4p, 1d6w, 1d9i, 1de7, 1dit, 1dm4, 1doj, 1dwb, 1dwc, 1dwd, 1dwe, 1dx5, 1e0f, 1eb1, 1eoj, 1eol, 1fpc, 1fph, 1g30, 1g32, 1g37, 1ghv, 1ghw, 1ghx, 1ghy, 1gj4, 1gj5, 1h8d, 1h8i, 1hag, 1hah, 1hai, 1hao, 1hap, 1hbt, 1hdt, 1hgt, 1hlt, 1hut, 1hxe, 1hxf, 1ihs, 1iht, 1jmo, 1jou, 1jwt, 1k21, 1k22, 1kts, 1ktt, 1lhc, 1lhd, 1lhe, 1lhf, 1lhg, 1mh0, 1mu6, 1mu8, 1mue, 1nm6, 1no9, 1nrn, 1nro, 1nrp, 1nrq, 1nrr, 1nrs, 1nt1, 1nu7, 1nu9, 1ny2, 1nzq, 1o0d, 1o2g, 1o5g, 1ook, 1oyt, 1p8v, 1ppb, 1qbv, 1qhr, 1qj1, 1qj6, 1qj7, 1qur, 1rd3, 1riw, 1sb1, 1sfq, 1sg8, 1sgi, 1shh, 1sl3, 1sr5, 1t4u, 1t4v, 1ta2, 1ta6, 1tb6, 1tbz, 1thp, 1thr, 1ths, 1tmb, 1tmt, 1tmu, 1tom, 1tq0, 1tq7, 1twx, 1ucy, 1uma, 1uvs, 1vit, 1vr1, 1vzq, 1w7g, 1way, 1wbg, 1xm1, 1xmn, 1ycp, 1ype, 1ypg, 1ypj, 1ypk, 1ypl, 1ypm, 1z71, 1z8i, 1z8j, 1zgi, 1zgv, 1zrb, 2a0q, 2a2x, 2a45, 2afq, 2ank, 2anm, 2b5t, 2bdy, 2bvr, 2bvs, 2bvx, 2bxt, 2bxu, 2c8w, 2c8x, 2c8y, 2c8z, 2c90, 2c93, 2cf8, 2cf9, 2cn0, 2feq, 2fes, 2gde, 2gp9, 2h9t, 2hgt, 2hnt, 2hpp, 2hpq, 2hwl, 2jh0, 2jh5, 2jh6, 2od3, 2thf, 3hat, 3htc, 4htc, 4thn, 5gds, 7kme, 8kme
标识
代号	F2; PT
扩展标识	遗传学：176930 鼠基因：88380 同源基因：426 GeneCards: F2 Gene
EC编号	3.4.21.5
基因本体论描述
分子功能	· thrombin activity; · receptor binding; · calcium ion binding;
细胞成分	· extracellular region; · extracellular space; · soluble fraction;
生物过程	· regulation of progression through cell cycle; · proteolysis; · apoptosis; · caspase activation; · acute-phase response; · tyrosine phosphorylation of STAT protein; · STAT protein nuclear translocation; · multicellular organismal development; · blood coagulation; · response to wounding; · platelet activation; · regulation of blood coagulation; · fibrinolysis;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	2147
Ensembl	ENSG00000180210
UniProt	P00734
mRNA序列	NM_000506
蛋白序列	NP_000497
基因位置	Chr 11:; 46.7 – 46.72 Mb
PubMed查询	[1]
	查; 论; 编;

凝血酶（英语：Thrombin，EC 3.4.21.5）是一种“胰蛋白酶样”丝氨酸蛋白酶蛋白质，在人体中被F2基因所编码^[2]^[3]。在凝血作用第一级级联反应中，凝血酶原（凝血因子Ⅱ）被蛋白水解性切除以生成凝血酶，级联反应最终阻止了血液的继续流失。凝血酶转而作为一种丝氨酸蛋白酶以使可溶性的纤维蛋白原转变为不溶性的纤维蛋白，同时催化其他许多与凝血相关的反应。

另见

参考文献

^ PDB 2C93; Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J. Med. Chem. February 2006, 49 (4): 1346–55. PMID 16480269. doi:10.1021/jm050850v.
^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Mol. Genet. May 1987, 13 (3): 285–92. PMID 3474786. doi:10.1007/BF01535211.
^ Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. September 1987, 26 (19): 6165–77. PMID 2825773. doi:10.1021/bi00393a033.

深入阅读

Esmon CT. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J. 1995, 9 (10): 946–55. PMID 7615164.
Lenting PJ, van Mourik JA, Mertens K. The life cycle of coagulation factor VIII in view of its structure and function. Blood. 1999, 92 (11): 3983–96. PMID 9834200.
Plow EF, Cierniewski CS, Xiao Z; et al. AlphaIIbbeta3 and its antagonism at the new millennium. Thromb. Haemost. 2002, 86 (1): 34–40. PMID 11487023.
Maragoudakis ME, Tsopanoglou NE, Andriopoulou P. Mechanism of thrombin-induced angiogenesis. Biochem. Soc. Trans. 2002, 30 (2): 173–7. PMID 12023846. doi:10.1042/BST0300173.
Howell DC, Laurent GJ, Chambers RC. Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochem. Soc. Trans. 2002, 30 (2): 211–6. PMID 12023853. doi:10.1042/BST0300211.
Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev. 2003, 23 (6): 824–54. PMID 12466191. doi:10.1210/er.2001-0033.
Minami T, Sugiyama A, Wu SQ; et al. Thrombin and phenotypic modulation of the endothelium. Arterioscler. Thromb. Vasc. Biol. 2004, 24 (1): 41–53. PMID 14551154. doi:10.1161/01.ATV.0000099880.09014.7D.
De Cristofaro R, De Candia E. Thrombin domains: structure, function and interaction with platelet receptors. J. Thromb. Thrombolysis. 2004, 15 (3): 151–63. PMID 14739624. doi:10.1023/B:THRO.0000011370.80989.7b.
Tsopanoglou NE, Maragoudakis ME. Role of thrombin in angiogenesis and tumor progression. Semin. Thromb. Hemost. 2004, 30 (1): 63–9. PMID 15034798. doi:10.1055/s-2004-822971.
Bode W. Structure and interaction modes of thrombin. Blood Cells Mol. Dis. 2007, 36 (2): 122–30. PMID 16480903. doi:10.1016/j.bcmd.2005.12.027.
Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev. 2007, 21 (3): 131–42. PMID 17208341. doi:10.1016/j.blre.2006.11.001.
Degen S: Prothrombin. In: High K, Roberts H, eds. Molecular Basis of Thrombosis and Hemostasis. New York, NY: Marcel Dekker; 1995:75.

外部链接

The MEROPS online database for peptidases and their inhibitors: S01.217（页面存档备份，存于互联网档案馆）
GeneReviews/NCBI/NIH/UW entry on Prothrombin Thrombophilia（页面存档备份，存于互联网档案馆）
[3]（页面存档备份，存于互联网档案馆） Anti-coagulation & proteases by The Proteolysis Map-animation
[4] PMAP: The Proteolysis Map/Thrombin

Template:凝固作用

[pmid16480269-1] PDB 2C93; Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J. Med. Chem. February 2006, 49 (4): 1346–55. PMID 16480269. doi:10.1021/jm050850v.

[pmid3474786-2] Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Mol. Genet. May 1987, 13 (3): 285–92. PMID 3474786. doi:10.1007/BF01535211.

[pmid2825773-3] Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. September 1987, 26 (19): 6165–77. PMID 2825773. doi:10.1021/bi00393a033.

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