胰蛋白酶

现有可用的蛋白结构：
Pfam	结构（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	结构概要
PDB	1uvu,H:367-615; 1hrt,H:367-616; 1bbr,E:517-616; 1tbq,K:367-616; 1ucy,E:517-616; 1uvt,H:367-616; 1tbr,H:367-616; 1a0h,E:367-616; 1etr,H:367-616; 1id5,H:367-616; 1ets,H:367-616; 1ett,H:367-616; 2a1d,F:367-616; 1dwc,H:364-613; 1rd3,D:364-613; 1hlt,H:364-613; 1qvh,E:364-613; 1h8i,H:364-613; 1nrq,H:364-613; 1jou,B:364-613; 1lhf,H:364-613; 1sg8,B:364-613; 1ny2,2:364-613; 1afe,H:364-613; 1de7,K:364-613; 1a3b,H:364-613; 1ghx,H:364-613; 1hap,H:364-613; 1dm4,B:364-613; 1dx5,P:364-613; 1bhx,F:518-613; 1riw,B:364-510; 1hxe,H:364-613; 1xmn,B:364-613; 1ktt,B:364-613; 1vr1,H:364-613; 1g30,B:364-613; 1a46,H:364-613; 1bmm,H:364-613; 1tmt,H:364-613; 1c4u,2:364-613; 1tq0,B:364-613; 1bb0,B:364-613; 1bth,H:364-613; 1nt1,A:364-613; 1ghv,H:364-613; 1shh,B:364-613; 1nu7,B:364-613; 1lhd,H:364-613; 1ypm,H:364-613; 1uvs,H:364-613; 1c1u,H:364-613; 1g32,B:364-613; 1gj4,H:364-613; 1hao,H:364-613; 1iht,H:364-613; 1z8i,B:364-613; 1awh,D:364-613; 1qj1,B:364-613; 1g37,A:364-613; 1tmu,H:364-613; 1d3p,B:364-613; 1uma,H:364-613; 1tq7,B:364-613; 1zgv,A:364-613; 1d9i,A:364-613; 1dwe,H:364-613; 1o0d,H:364-613; 1ae8,H:364-613; 1nzq,H:364-613; 1gj5,H:364-613; 1nu9,D:364-613; 1d6w,A:364-613; 1e0f,D:364-613; 1lhe,H:364-613; 1t4u,H:364-613; 1abi,H:364-613; 1c1w,H:364-613; 2hpp,H:364-613; 2hpq,H:364-613; 1no9,H:364-613; 1dit,H:364-613; 1nrr,H:364-613; 1qbv,H:364-613; 2hnt,F:520-613; 1o5g,H:364-613; 1zrb,A:364-613; 1c5l,H:364-613; 1eb1,H:364-613; 1xm1,A:364-613; 1a5g,H:364-613; 1nrp,H:364-613; 1nro,H:364-613; 1sr5,C:364-613; 2afq,D:364-613; 1c4y,2:364-613; 1jwt,A:364-613; 1ypg,H:364-613; 1c5o,H:364-613; 1qj6,B:364-613; 1b5g,H:364-613; 1hah,H:364-613; 1lhg,H:364-613; 1a2c,H:364-613; 1c5n,H:364-613; 1sl3,A:364-613; 1ths,H:364-613; 1mu6,B:364-613; 1bmn,H:364-613; 1nrn,H:364-613; 1fpc,H:364-613; 1sfq,E:364-613; 1qur,H:364-613; 1hbt,H:364-613; 1ype,H:364-613; 1jmo,H:364-613; 1ta6,A:364-613; 4htc,H:364-613; 1aht,H:364-613; 1k22,H:364-613; 1d3d,B:364-613; 1ppb,H:364-613; 1nm6,A:364-613; 1a3e,H:364-613; 1ai8,H:364-613; 1mue,B:364-613; 1ca8,B:364-613; 1eol,A:364-613; 1sb1,H:364-613; 1dwb,H:364-613; 1aix,H:364-613; 7kme,H:364-613; 3hat,H:364-613; 1hxf,H:364-613; 1hdt,H:364-613; 1qj7,B:364-613; 1zgi,A:364-613; 1way,B:364-613; 1mh0,A:364-613; 1b7x,B:364-613; 1kts,B:364-613; 1ghy,H:364-613; 2hgt,H:364-613; 1k21,H:364-613; 1hut,H:364-613; 1sgi,B:364-613; 1abj,H:364-613; 1lhc,H:364-613; 1o2g,H:364-613; 1ypk,H:364-613; 1ay6,H:364-613; 1thp,B:364-613; 1qhr,B:364-613; 1z8j,B:364-613; 1hag,E:364-613; 5gds,H:364-613; 1bcu,H:364-613; 1d4p,B:364-613; 1doj,A:364-613; 1tom,H:364-613; 1p8v,C:364-613; 1h8d,H:364-613; 1tbz,H:364-613; 1tb6,H:364-613; 1dwd,H:364-613; 1ihs,H:364-613; 2thf,B:364-613; 1c4v,2:364-613; 1ba8,B:364-613; 1ypj,H:364-613; 1a4w,H:364-613; 1ook,B:364-613; 1hgt,H:364-613; 1nrs,H:364-613; 1twx,B:364-613; 1ypl,H:364-613; 4thn,H:364-613; 1t4v,H:364-613; 1tmb,H:364-613; 1d3q,B:364-613; 1vzq,H:364-613; 8kme,2:364-613; 1ta2,A:364-613; 1a61,H:364-613; 1thr,H:364-613; 1fph,H:364-613; 2a0q,B:364-613; 1ad8,H:364-613; 1mu8,B:364-613; 1ghw,H:364-613; 1c1v,H:364-613; 1d3t,B:364-613; 1awf,H:364-613; 1oyt,H:364-613; 1hai,H:364-613; 1z71,A:364-613; 1eoj,A:364-613; 1pq8,A:25-244; 1pqa,A:25-244; 1fn8,A:25-244; 1pq7,A:25-244; 1pq5,A:25-244; 1xvo,A:25-244; 1ppz,A:25-244; 1gdu,A:25-244; 1fy4,A:25-244; 1gdn,A:25-244; 1xvm,A:25-244; 1fy5,A:25-244; 1gdq,A:25-244; 1try,25-244; 1sgt,37-252; 1os8,A:37-252; 1oss,A:37-252; 1kdq,B:165-256; 1mtn,F:16-146; 1k2i,1:16-238; 1ab9,B:16-146; 1cbw,G:16-146; 1gg6,C:149-238; 1gl1,C:16-238; 6gch,G:151-238; 1ca0,H:149-238; 1t8n,C:16-238; 1ghb,F:16-146; 6cha,B:16-146; 1acb,E:16-238; 2cha,B:16-146; 2gmt,16-238; 1oxg,A:16-238; 1hja,C:149-238; 1t7c,C:16-238; 1t8o,A:16-238; 1dlk,D:16-238; 5gch,G:151-238; 5cha,B:16-146; 1p2n,A:16-238; 1gmc,F:16-146; 3gct,G:151-238; 1gmh,G:150-238; 1t8m,C:16-238; 7gch,G:151-238; 1cho,F:16-146; 1gha,G:151-238; 4vgc,C:151-238; 1cgj,E:16-238; 4cha,B:16-146; 1t8l,C:16-238; 1ex3,A:16-238; 2gch,F:16-146; 1ggd,C:149-238; 1n8o,C:149-238; 2vgc,B:16-146; 2gct,F:16-146; 1afq,B:16-146; 2cga,A:16-238; 1vgc,B:16-146; 1p2o,A:16-238; 1gmd,G:151-238; 1cgi,E:16-238; 4gch,G:151-238; 1gl0,E:16-238; 1p2m,C:16-238; 3vgc,B:16-146; 8gch,B:16-146; 1p2q,A:16-238; 1chg,16-238; 1gcd,16-238; 1fon,B:22-246; 1pyt,C:12-246; 1bru,P:29-262; 1elt,1-232; 1e38,B:27-259; 1nes,E:27-259; 2a7c,A:27-259; 1e37,B:27-259; 1haz,B:27-259; 1uvo,A:27-259; 2a7j,A:27-259; 1b0e,A:27-259; 1l0z,A:27-259; 1mcv,A:27-259; 7est,E:27-259; 4est,E:27-259; 6est,27-259; 9est,27-259; 8est,E:27-259; 2est,E:27-259; 1elf,27-259; 1qix,B:27-259; 1elc,A:27-259; 1hv7,A:27-259; 3est,27-259; 1e35,B:27-259; 2blq,A:27-259; 1c1m,A:27-259; 1qgf,A:27-259; 1inc,27-259; 1e34,B:27-259; 1uvp,A:27-259; 1hax,B:27-259; 1eat,27-259; 1l1g,A:27-259; 5est,E:27-259; 1ele,E:27-259; 1qr3,E:27-259; 1elb,A:27-259; 1hb0,B:27-259; 1uo6,A:27-259; 1okx,A:27-259; 1lvy,27-259; 1fzz,A:27-259; 1eau,27-259; 1gvk,B:27-259; 1e36,B:27-259; 1elg,27-259; 1fle,E:27-259; 2blo,A:27-259; 1est,27-259; 1eld,E:27-259; 1h9l,B:27-259; 1esb,27-259; 1eai,B:27-259; 1gwa,A:27-259; 1btu,27-259; 1qnj,A:27-259; 1lka,A:27-259; 1jim,27-259; 1lkb,A:27-259; 1mmj,N:27-259; 1hay,B:27-259; 1eas,27-259; 1ela,A:27-259; 1esa,27-259; 2d26,C:27-259; 1bma,A:27-259; 1ekb,B:801-1030; 1o5e,H:163-400; 1z8g,A:163-400; 1o5f,H:163-400; 1p57,B:163-400; 2anw,A:391-621; 2any,A:391-621; 1xxf,B:388-618; 1zjd,A:388-618; 1zhm,A:388-618; 1zhp,A:388-618; 1xxd,B:388-618; 1xx9,B:388-618; 1zhr,A:388-618; 1eaw,A:615-849; 1eax,A:615-849; 1qrz,B:581-803; 1l4d,A:581-803; 1bui,A:581-803; 1bml,B:581-803; 1ddj,C:581-803; 1rjx,B:581-803; 1l4z,A:581-803; 2bm2,B:31-267; 1a0l,A:31-267; 1aao,31-267; 1lto,A:31-267

胰蛋白酶
胰蛋白酶
	Crystal structure of bovine trypsin.
鉴定
标志	Trypsin
Pfam	PF00089（旧版）
InterPro（英语：InterPro）	IPR001254
SMART（英语：Simple Modular Architecture Research Tool）	SM00020
PROSITE（英语：PROSITE）	PDOC00124
MEROPS	S1
SCOP（英语：Structural Classification of Proteins）	1c2g / SUPFAM
Pfam
现有可用的蛋白结构：
Pfam	结构（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	结构概要
PDB	1uvu,H:367-615; 1hrt,H:367-616; 1bbr,E:517-616; 1tbq,K:367-616; 1ucy,E:517-616; 1uvt,H:367-616; 1tbr,H:367-616; 1a0h,E:367-616; 1etr,H:367-616; 1id5,H:367-616; 1ets,H:367-616; 1ett,H:367-616; 2a1d,F:367-616; 1dwc,H:364-613; 1rd3,D:364-613; 1hlt,H:364-613; 1qvh,E:364-613; 1h8i,H:364-613; 1nrq,H:364-613; 1jou,B:364-613; 1lhf,H:364-613; 1sg8,B:364-613; 1ny2,2:364-613; 1afe,H:364-613; 1de7,K:364-613; 1a3b,H:364-613; 1ghx,H:364-613; 1hap,H:364-613; 1dm4,B:364-613; 1dx5,P:364-613; 1bhx,F:518-613; 1riw,B:364-510; 1hxe,H:364-613; 1xmn,B:364-613; 1ktt,B:364-613; 1vr1,H:364-613; 1g30,B:364-613; 1a46,H:364-613; 1bmm,H:364-613; 1tmt,H:364-613; 1c4u,2:364-613; 1tq0,B:364-613; 1bb0,B:364-613; 1bth,H:364-613; 1nt1,A:364-613; 1ghv,H:364-613; 1shh,B:364-613; 1nu7,B:364-613; 1lhd,H:364-613; 1ypm,H:364-613; 1uvs,H:364-613; 1c1u,H:364-613; 1g32,B:364-613; 1gj4,H:364-613; 1hao,H:364-613; 1iht,H:364-613; 1z8i,B:364-613; 1awh,D:364-613; 1qj1,B:364-613; 1g37,A:364-613; 1tmu,H:364-613; 1d3p,B:364-613; 1uma,H:364-613; 1tq7,B:364-613; 1zgv,A:364-613; 1d9i,A:364-613; 1dwe,H:364-613; 1o0d,H:364-613; 1ae8,H:364-613; 1nzq,H:364-613; 1gj5,H:364-613; 1nu9,D:364-613; 1d6w,A:364-613; 1e0f,D:364-613; 1lhe,H:364-613; 1t4u,H:364-613; 1abi,H:364-613; 1c1w,H:364-613; 2hpp,H:364-613; 2hpq,H:364-613; 1no9,H:364-613; 1dit,H:364-613; 1nrr,H:364-613; 1qbv,H:364-613; 2hnt,F:520-613; 1o5g,H:364-613; 1zrb,A:364-613; 1c5l,H:364-613; 1eb1,H:364-613; 1xm1,A:364-613; 1a5g,H:364-613; 1nrp,H:364-613; 1nro,H:364-613; 1sr5,C:364-613; 2afq,D:364-613; 1c4y,2:364-613; 1jwt,A:364-613; 1ypg,H:364-613; 1c5o,H:364-613; 1qj6,B:364-613; 1b5g,H:364-613; 1hah,H:364-613; 1lhg,H:364-613; 1a2c,H:364-613; 1c5n,H:364-613; 1sl3,A:364-613; 1ths,H:364-613; 1mu6,B:364-613; 1bmn,H:364-613; 1nrn,H:364-613; 1fpc,H:364-613; 1sfq,E:364-613; 1qur,H:364-613; 1hbt,H:364-613; 1ype,H:364-613; 1jmo,H:364-613; 1ta6,A:364-613; 4htc,H:364-613; 1aht,H:364-613; 1k22,H:364-613; 1d3d,B:364-613; 1ppb,H:364-613; 1nm6,A:364-613; 1a3e,H:364-613; 1ai8,H:364-613; 1mue,B:364-613; 1ca8,B:364-613; 1eol,A:364-613; 1sb1,H:364-613; 1dwb,H:364-613; 1aix,H:364-613; 7kme,H:364-613; 3hat,H:364-613; 1hxf,H:364-613; 1hdt,H:364-613; 1qj7,B:364-613; 1zgi,A:364-613; 1way,B:364-613; 1mh0,A:364-613; 1b7x,B:364-613; 1kts,B:364-613; 1ghy,H:364-613; 2hgt,H:364-613; 1k21,H:364-613; 1hut,H:364-613; 1sgi,B:364-613; 1abj,H:364-613; 1lhc,H:364-613; 1o2g,H:364-613; 1ypk,H:364-613; 1ay6,H:364-613; 1thp,B:364-613; 1qhr,B:364-613; 1z8j,B:364-613; 1hag,E:364-613; 5gds,H:364-613; 1bcu,H:364-613; 1d4p,B:364-613; 1doj,A:364-613; 1tom,H:364-613; 1p8v,C:364-613; 1h8d,H:364-613; 1tbz,H:364-613; 1tb6,H:364-613; 1dwd,H:364-613; 1ihs,H:364-613; 2thf,B:364-613; 1c4v,2:364-613; 1ba8,B:364-613; 1ypj,H:364-613; 1a4w,H:364-613; 1ook,B:364-613; 1hgt,H:364-613; 1nrs,H:364-613; 1twx,B:364-613; 1ypl,H:364-613; 4thn,H:364-613; 1t4v,H:364-613; 1tmb,H:364-613; 1d3q,B:364-613; 1vzq,H:364-613; 8kme,2:364-613; 1ta2,A:364-613; 1a61,H:364-613; 1thr,H:364-613; 1fph,H:364-613; 2a0q,B:364-613; 1ad8,H:364-613; 1mu8,B:364-613; 1ghw,H:364-613; 1c1v,H:364-613; 1d3t,B:364-613; 1awf,H:364-613; 1oyt,H:364-613; 1hai,H:364-613; 1z71,A:364-613; 1eoj,A:364-613; 1pq8,A:25-244; 1pqa,A:25-244; 1fn8,A:25-244; 1pq7,A:25-244; 1pq5,A:25-244; 1xvo,A:25-244; 1ppz,A:25-244; 1gdu,A:25-244; 1fy4,A:25-244; 1gdn,A:25-244; 1xvm,A:25-244; 1fy5,A:25-244; 1gdq,A:25-244; 1try,25-244; 1sgt,37-252; 1os8,A:37-252; 1oss,A:37-252; 1kdq,B:165-256; 1mtn,F:16-146; 1k2i,1:16-238; 1ab9,B:16-146; 1cbw,G:16-146; 1gg6,C:149-238; 1gl1,C:16-238; 6gch,G:151-238; 1ca0,H:149-238; 1t8n,C:16-238; 1ghb,F:16-146; 6cha,B:16-146; 1acb,E:16-238; 2cha,B:16-146; 2gmt,16-238; 1oxg,A:16-238; 1hja,C:149-238; 1t7c,C:16-238; 1t8o,A:16-238; 1dlk,D:16-238; 5gch,G:151-238; 5cha,B:16-146; 1p2n,A:16-238; 1gmc,F:16-146; 3gct,G:151-238; 1gmh,G:150-238; 1t8m,C:16-238; 7gch,G:151-238; 1cho,F:16-146; 1gha,G:151-238; 4vgc,C:151-238; 1cgj,E:16-238; 4cha,B:16-146; 1t8l,C:16-238; 1ex3,A:16-238; 2gch,F:16-146; 1ggd,C:149-238; 1n8o,C:149-238; 2vgc,B:16-146; 2gct,F:16-146; 1afq,B:16-146; 2cga,A:16-238; 1vgc,B:16-146; 1p2o,A:16-238; 1gmd,G:151-238; 1cgi,E:16-238; 4gch,G:151-238; 1gl0,E:16-238; 1p2m,C:16-238; 3vgc,B:16-146; 8gch,B:16-146; 1p2q,A:16-238; 1chg,16-238; 1gcd,16-238; 1fon,B:22-246; 1pyt,C:12-246; 1bru,P:29-262; 1elt,1-232; 1e38,B:27-259; 1nes,E:27-259; 2a7c,A:27-259; 1e37,B:27-259; 1haz,B:27-259; 1uvo,A:27-259; 2a7j,A:27-259; 1b0e,A:27-259; 1l0z,A:27-259; 1mcv,A:27-259; 7est,E:27-259; 4est,E:27-259; 6est,27-259; 9est,27-259; 8est,E:27-259; 2est,E:27-259; 1elf,27-259; 1qix,B:27-259; 1elc,A:27-259; 1hv7,A:27-259; 3est,27-259; 1e35,B:27-259; 2blq,A:27-259; 1c1m,A:27-259; 1qgf,A:27-259; 1inc,27-259; 1e34,B:27-259; 1uvp,A:27-259; 1hax,B:27-259; 1eat,27-259; 1l1g,A:27-259; 5est,E:27-259; 1ele,E:27-259; 1qr3,E:27-259; 1elb,A:27-259; 1hb0,B:27-259; 1uo6,A:27-259; 1okx,A:27-259; 1lvy,27-259; 1fzz,A:27-259; 1eau,27-259; 1gvk,B:27-259; 1e36,B:27-259; 1elg,27-259; 1fle,E:27-259; 2blo,A:27-259; 1est,27-259; 1eld,E:27-259; 1h9l,B:27-259; 1esb,27-259; 1eai,B:27-259; 1gwa,A:27-259; 1btu,27-259; 1qnj,A:27-259; 1lka,A:27-259; 1jim,27-259; 1lkb,A:27-259; 1mmj,N:27-259; 1hay,B:27-259; 1eas,27-259; 1ela,A:27-259; 1esa,27-259; 2d26,C:27-259; 1bma,A:27-259; 1ekb,B:801-1030; 1o5e,H:163-400; 1z8g,A:163-400; 1o5f,H:163-400; 1p57,B:163-400; 2anw,A:391-621; 2any,A:391-621; 1xxf,B:388-618; 1zjd,A:388-618; 1zhm,A:388-618; 1zhp,A:388-618; 1xxd,B:388-618; 1xx9,B:388-618; 1zhr,A:388-618; 1eaw,A:615-849; 1eax,A:615-849; 1qrz,B:581-803; 1l4d,A:581-803; 1bui,A:581-803; 1bml,B:581-803; 1ddj,C:581-803; 1rjx,B:581-803; 1l4z,A:581-803; 2bm2,B:31-267; 1a0l,A:31-267; 1aao,31-267; 1lto,A:31-267

胰蛋白酶
命名
系统命名
缩写
识别码
EC编号	3.4.21.4
CAS号	9002-07-7
数据库
IntEnz	IntEnz浏览
BRENDA（英语：BRENDA）	BRENDA入口
ExPASy（英语：ExPASy）	NiceZyme浏览
KEGG	KEGG入口
MetaCyc（英语：MetaCyc）	代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本体	AmiGO / EGO
搜索
PMC	相关文献
PubMed	相关文献

胰蛋白酶（英语：Trypsin）是一种酶。

胰蛋白酶在小肠工作，它会将蛋白质水解为肽，进而分解为氨基酸。这是蛋白质能被人体吸收的必要过程。这种酶的作用原理和其他丝氨酸蛋白酶差不多。

胰蛋白酶的最佳pH值约为8，温度约为37℃。

胰脏制造的是没有活性的胰蛋白酶原。它分泌到小肠后，小肠内的肠肽酶会活化它，令它成为胰蛋白酶。已经变成胰蛋白酶的，能活化更多胰蛋白酶原，这种过程即自动催化，所以只需少量肠肽酶便能开始消化反应。这种过程能避免胰脏被活化的酶消化。

切割位点

胰蛋白酶选择地水解蛋白质中所有的由赖氨酸Lys或精氨酸Arg的羧基所构成的肽键。如果脯氨酸Pro残基位于切割位点的羧基侧，则不发生切割。

同工酶

下列人类基因编码具有胰蛋白酶活性的蛋白质：

蛋白酶，丝氨酸，1 （胰蛋白酶1）
识别
符号	PRSS1
替换符号	TRY1
Entrez	5644
HUGO	9475
OMIM	276000
RefSeq	NM_002769
UniProt	P07477
其他资料
EC编号	3.4.21.4
基因座	7 q32-qter

蛋白酶，丝氨酸，2 （胰蛋白酶2）
识别
符号	PRSS2
替换符号	TRYP2
Entrez	5645
HUGO	9483
OMIM	601564
RefSeq	NM_002770
UniProt	P07478
其他资料
EC编号	3.4.21.4
基因座	7 q35

蛋白酶，丝氨酸，3（中胰蛋白酶）
识别
符号	PRSS3
替换符号	PRSS4
Entrez	5646
HUGO	9486
OMIM	613578
RefSeq	NM_002771
UniProt	P35030
其他资料
EC编号	3.4.21.4
基因座	9 p13

参考文献

^ PDB 1UTN; Leiros HK, Brandsdal BO, Andersen OA, Os V, Leiros I, Helland R, Otlewski J, Willassen NP, Smalås AO. Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements. Protein Sci. April 2004, 13 (4): 1056–70. PMC 2280040  . PMID 15044735. doi:10.1110/ps.03498604.

[pmid15044735-1] PDB 1UTN; Leiros HK, Brandsdal BO, Andersen OA, Os V, Leiros I, Helland R, Otlewski J, Willassen NP, Smalås AO. Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements. Protein Sci. April 2004, 13 (4): 1056–70. PMC 2280040  . PMID 15044735. doi:10.1110/ps.03498604.

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