去甲汉黄芩素

化合物

去甲汉黄芩素(英语:Norwogonin,也称为5,7,8-三羟基黄酮,5,7,8-trihydroxyflavone,缩写5,7,8-THF)是一种天然黄酮类化合物,存在于黄芩(学名:Scutellaria baicalensis)等植物中[1]。其生物学活性接近7,8-二羟基黄酮(7,8-DHF)[2]

去甲汉黄芩素
临床资料
其他名称5,7,8-Trihydroxyflavone; 5,7,8-THF
识别信息
  • 5,7,8-trihydroxy-2-phenylchromen-4-one
CAS号4443-09-8
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C15H10O5
摩尔质量270.24 g·mol−1
3D模型(JSmol英语JSmol
  • C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O
  • InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H
  • Key:ZFKKRRMUPBBYRS-UHFFFAOYSA-N

参考文献

编辑
  1. ^ Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, et al. Khan AU , 编. Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii. PLOS ONE. 2013, 8 (4): e61594. Bibcode:2013PLoSO...861594M. PMC 3632535 . PMID 23630600. doi:10.1371/journal.pone.0061594. 
  2. ^ Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. Journal of Medicinal Chemistry. December 2010, 53 (23): 8274–86. PMC 3150605 . PMID 21073191. doi:10.1021/jm101206p.